1321909-48-1

Basic information

• Product Name: C₁₃H₂₂FNOSi₂
• Synonyms: C₁₃H₂₂FNOSi₂
• CAS NO: 1321909-48-1
• Molecular Weight: 283.493
• Mol File: 1321909-48-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₃H₂₂FNOSi₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₂₂FNOSi₂(1321909-48-1)
• EPA Substance Registry System: C₁₃H₂₂FNOSi₂(1321909-48-1)

Safety Data

• Hazardous Substances Data: 1321909-48-1(Hazardous Substances Data)

Upstream product

• 403-43-0 4-fluorobenzoyl chloride 
• 4039-32-1 lithium hexamethyldisilazane 

Downstream Products

• 1194-02-1 4-fluorobenzonitrile 

Relevant articles and documents

Copper-catalyzed dehydration of primary amides to nitriles

In the present study we introduce a copper-catalyzed protocol for the dehydration of primary amides to their corresponding nitriles applying N-methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) as silylation reagent. For that purpose investigations of various reaction parameters (copper source, solvent, temperature, MSTFA and copper loading) have been carried out to find suitable reaction conditions. Simple copper(I) chloride (2.5 mol%) and MSTFA (2.0 equiv) in toluene allow for the straightforward synthesis of a variety of nitriles (15 examples).