1333519-82-6

Basic information

• Product Name: (Z)-4-(((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amino)-1,1,1-trifluoro-4-(4-nitrophenyl)but-3-en-2-one
• Synonyms: (Z)-4-(((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amino)-1,1,1-trifluoro-4-(4-nitrophenyl)but-3-en-2-one
• CAS NO: 1333519-82-6
• Molecular Weight: 431.374
• Mol File: 1333519-82-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Z)-4-(((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amino)-1,1,1-trifluoro-4-(4-nitrophenyl)but-3-en-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-4-(((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amino)-1,1,1-trifluoro-4-(4-nitrophenyl)but-3-en-2-one(1333519-82-6)
• EPA Substance Registry System: (Z)-4-(((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amino)-1,1,1-trifluoro-4-(4-nitrophenyl)but-3-en-2-one(1333519-82-6)

Safety Data

• Hazardous Substances Data: 1333519-82-6(Hazardous Substances Data)

Upstream product

• 1333519-78-0 (1-benzyl-1H-1,2,3-triazol-4-yl)methanaminium 2,2,2-trifluoroacetate 
• 164470-92-2 (Z)-1,1,1-trifluoro-4-methoxy-4-(4-nitrophenyl)but-3-en-2-one 
• 53577-98-3 1-(1,1-dimethoxyethyl)-4-nitrobenzene 

Relevant articles and documents

ClickEnam. 1. Synthesis of novel 1,4-disubsituted-[1,2,3]-triazole-derived β-aminovinyl trifluoromethylated ketones and their copper(II) complexes

The copper(I) catalyzed cycloaddition reaction of N-Boc propargyl amine (dipolarophile) 1 with benzyl azide (1,3-dipole) 2 was found to proceed smoothly in t-BuOH/H2O at room temperature, to furnish the corresponding 1,4-disubstituted-[1,2,3]-triazole-derived N-Boc amine 3 in good yield. Deprotection of 3 with trifluoroacetic acid and addition of the trifluoroacetate salt 4 in the presence of triethylamine, with a series of methoxyvinyl(trifluoromethyl)ketones 10-14, gave the corresponding β-aminovinyl trifluoromethylated ketones 15-19 in moderate to good yields. Two copper(II) complexes, one monomer and one dimer with chlorine double bridge, 20 and 21, respectively, were also prepared and their crystal structure determined. β-Aminovinyl trifluoromethylated ketones 15-17 and complexes 20 and 21 have been screened as potential antifungal agents and the antimalarial activity of 15 and 16 were tested against two Plasmodium falciparum strains (3D7 and W2).