1334108-11-0Relevant articles and documents
Design and synthesis of novel amide AKT1 inhibitors with selectivity over CDK2
Ashton, Kate S.,St. Jean Jr., David J.,Poon, Steve F.,Lee, Matthew R.,Allen, John G.,Zhang, Shiwen,Lofgren, Julie A.,Zhang, Xiaoling,Fotsch, Christopher,Hungate, Randall
, p. 5191 - 5196 (2011)
Through the analysis of X-ray crystallographic information and previous SAR studies, a novel series of protein kinase B (PKB/AKT) inhibitors was developed. The compounds showed nanomolar inhibition of AKT1 and were selective against cyclin-dependent kinas
