1334294-10-8

Basic information

• Product Name: C₉H₅ClFNO₂S*ClH
• CAS NO: 1334294-10-8
• Molecular Weight: 282.123
• Mol File: 1334294-10-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₉H₅ClFNO₂S*ClH(CAS DataBase Reference)
• NIST Chemistry Reference: C₉H₅ClFNO₂S*ClH(1334294-10-8)
• EPA Substance Registry System: C₉H₅ClFNO₂S*ClH(1334294-10-8)

Safety Data

• Hazardous Substances Data: 1334294-10-8(Hazardous Substances Data)

Upstream product

• 394-67-2 4--fluoroisoquinoline 
• 906820-09-5 4-fluoroisoquinoline sulfate 

Relevant articles and documents

A Practical synthesis of novel Rho-kinase inhibitor, (S)-4-fluoro-5-(2- methyl-1,4-diazepan-1-ylsulfonyl)-isoquinoline

A practical synthesis of novel Rho-kinase inhibitor, (S)-4-fluoro-5- (2-methyl-1,4-diazepan-1-ylsulfonyl)isoquinoline hydrochloride dihydrate (1) was achieved in a pilot-scale production. We have demonstrated the regioselective chlorosulfonylation of 4-fluoroisoquinoline in an one-pot reaction to afford 4-fluoroisoquinoline-5-sulfonyl chloride and the asymmetric construction of the (S)-2-methyl-1,4-diazepane moiety as key steps. The Japan Institute of Heterocyclic Chemistry.