133645-53-1

Basic information

• Product Name: BOC-D-HOMOSER-OBZL
• Synonyms: BOC-D-HOMOSER-OBZL;N-Boc-D-homoserine benzyl ester
• CAS NO: 133645-53-1
• Molecular Formula: C₁₆H₂₃NO₅
• Molecular Weight: 309.35752
• Mol File: 133645-53-1.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BOC-D-HOMOSER-OBZL(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-D-HOMOSER-OBZL(133645-53-1)
• EPA Substance Registry System: BOC-D-HOMOSER-OBZL(133645-53-1)

Safety Data

• Hazardous Substances Data: 133645-53-1(Hazardous Substances Data)

Upstream product

• 745011-75-0 (R)-2-((tert-butoxycarbonyl)amino)-4-hydroxybutanoic acid 
• 100-39-0 benzyl bromide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 92828-64-3 (R)-2-tert-butoxycarbonylamino-succinic acid 1-benzyl ester 
• 100-44-7 benzyl chloride 
• 68719-38-0 N-Boc-potassium L-homoserine 

Downstream Products

• 25691-37-6 (α)N-1,1-dimethylethoxycarbonyl-L-2,4-diaminobutyric acid 
• 305322-27-4 (1S,3R,2'R)-2-benzyl-1-[2'-benzyloxycarbonyl-2'-(tert-butoxycarbonyl)aminoethyl]-3-methoxycarbonyl-1,2,3,4-tetrahydro-β-carboline 
• 305322-35-4 (2R,5R,11bS,1'S)-2-(tert-butoxycarbonyl)amino-5-(1'-methoxycarbonyl-2'-phenylethyl)carbamoyl-3-oxo-2,3,5,6,11,11b-hexahydro-1H-indolizino[8,7-b]indole 
• 918650-35-8 phenylmethyl (2R)-4-(3-{(2S)-2-[(3,3-dimethyl-3-silabutyl)oxycarbonyl]-2-[(phenylmethoxy)carbonylamino]ethyl}phenoxy)-2-[(tert-butoxy)carbonylamino]butanoate 
• 134676-02-1 Boc-D-Asp(H)-OBzl 
• 116393-76-1 N-Boc O-tosyl L-homoserine benzyl ester 
• 116393-77-2 N-Boc O-benzenesulphonyl L-homoserine benzyl ester 

Relevant articles and documents

Design and Optimization of an Acyclic Amine Series of TRPV4 Antagonists by Electronic Modulation of Hydrogen Bond Interactions

Investigation of TRPV4 as a potential target for the treatment of pulmonary edema associated with heart failure generated a novel series of acyclic amine inhibitors displaying exceptional potency and PK properties. The series arose through a scaffold hopp

2,4-diaminobutyric acid derivative and preparation method thereof

The invention relates to a 2,4-diaminobutyric acid derivative and a preparation method thereof and relates to the field of medicine synthesis. An aspartic acid derivative serves as an initiator, and the 2,4-diaminobutyric acid derivative is obtained through simple reduction and substitution reaction. Different from the prior art, a reagent adopted for the method is small in toxicity, reaction conditions are mild, requirements for a device are not high, synthesis steps are simple, the 2,4-diaminobutyric acid derivative can be obtained at a high total yield, and the 2,4-diaminobutyric acid derivative facilitates large-scale industrial production and can be well applied to medicine synthesis.

A novel dipeptide, N-γ-glutamyl boletine, and a cyclic iminium toxin from the mushroom Tylopilus sp. (Boletaceae)

N-γ-Glutamyl boletine and a toxin, 2-butyl-1-azacyclohexene iminium salt, were isolated from the mushroom Tylopilus sp. (Boltaceae). The absolute stereostructure of N-γ-glutamyl boletine was clarified based on spectroscopic analysis, acidic hydrolysis and total synthesis. N-γ-Glutamyl boletine exhibited moderate antibacterial activity. 2-Butyl-1-azacyclohexene iminium salt exhibited moderate acute toxicity against ddY mice. We proposed feasible biosynthetic pathway of piperidine alkaloids that the cyclic iminium compound might be biosynthesized from boletine, a new amino acid containing an δ-amino ketone moiety.