13367-85-6 Usage
Description
Prostaglandin B2 (PGB2) is a non-enzymatic dehydration product derived from the treatment of PGE2 or PGA2 with a strong base. It is an abundant prostaglandin released from osteoblasts and possesses weak agonist activity on TP receptors. PGB2 can increase pulmonary blood pressure in rabbits at relatively high doses. The PGB2 MaxSpec standard is a quantitative grade standard specifically prepared for mass spectrometry or applications requiring quantitative reproducibility, ensuring identity, purity, stability, and concentration specifications.
Uses
1. Used in Pharmaceutical Applications:
Prostaglandin B2 is used as a quantitative grade standard for mass spectrometry and other applications requiring precise reproducibility. It helps in maintaining accurate concentration measurements and ensuring product quality.
2. Used in Research and Development:
Prostaglandin B2 is utilized in research and development for studying its effects on TP receptors and its potential role in increasing pulmonary blood pressure in rabbits. This aids in understanding the underlying mechanisms and exploring possible therapeutic applications.
3. Used in Quality Control and Assurance:
The PGB2 MaxSpec standard is employed in quality control and assurance processes to verify the concentration of PGB2 in various products and ensure that they meet the required specifications throughout their shelf life.
4. Used in Osteoblast Research:
As an abundant prostaglandin released from osteoblasts, Prostaglandin B2 is used in the study of bone metabolism, bone formation, and related cellular processes, contributing to a better understanding of bone health and diseases.
5. Used in Drug Development:
Prostaglandin B2 may be used in the development of new drugs targeting TP receptors or related pathways, potentially leading to novel therapeutic approaches for various conditions.
6. Used in Analytical Chemistry:
The PGB2 MaxSpec standard is utilized in analytical chemistry for the accurate quantification of PGB2 in samples, ensuring the reliability of results and facilitating the development of new analytical methods.
Check Digit Verification of cas no
The CAS Registry Mumber 13367-85-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,3,6 and 7 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 13367-85:
(7*1)+(6*3)+(5*3)+(4*6)+(3*7)+(2*8)+(1*5)=106
106 % 10 = 6
So 13367-85-6 is a valid CAS Registry Number.
InChI:InChI=1/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m1/s1
13367-85-6Relevant articles and documents
Daniels et al.
, p. 1298 (1967)
SYNTHESIS OF FLUORODESOXYPROSTAGLANDIN E2
Bezuglov, V. V.,Serkov, I. V.,Gafurov, R. G.,Bergel'son, L. D.
, p. 264 - 266 (2007/10/02)
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Prostaglandins and congeners. XXII. Synthesis of 11-substituted derivatives of 11-de-oxyprostaglandins E1 and E2. Potential bronchodilators
Floyd,Schaub,Siuta,et al.
, p. 903 - 913 (2007/10/02)
The interesting bronchodilator activity of l-11-deoxy-11α-[(2-hydroxyethyl)thiolprostaglandin E2 methyl ester (3a) is described. The preparation of 3a and its analogues by Michael-type additions to various members of the PGA series or by total synthesis using the lithiocuprate conjugate addition process is also described. Structure-activity relationships in this series are discussed.
