1346665-08-4

Basic information

• Product Name: 5-methyl-2-phenyl-4-(4-phenylthiazol-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one
• CAS NO: 1346665-08-4
• Molecular Weight: 334.401
• Mol File: 1346665-08-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-methyl-2-phenyl-4-(4-phenylthiazol-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-2-phenyl-4-(4-phenylthiazol-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one(1346665-08-4)
• EPA Substance Registry System: 5-methyl-2-phenyl-4-(4-phenylthiazol-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one(1346665-08-4)

Safety Data

• Hazardous Substances Data: 1346665-08-4(Hazardous Substances Data)

Upstream product

• 508191-77-3 3-phenylsydnone 
• 28740-63-8 5-methyl-3-phenyl-1,3,4-oxadiazol-2(3H)-one 
• 1346665-07-3 C₁₀H₁₀N₄OS 
• 70-11-1 α-bromoacetophenone 

Relevant articles and documents

Facile TICl4-catalyzed synthesis of novel 1,2,4-triazoles appended to thiazoles

The reaction of sydnone-derived 3-aryl-5-methyl-1,3,4-oxadiazol-2(3H)-ones with thiourea and α-bromoacetophenone derivatives in the presence of a catalytic amount of TiCl4 produces 2-aryl-4-(4-aryl-1,3-thiazol-2-yl) -5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-ones. The title compounds were screened for their antibacterial and antifungal activity. The toxicity of the compounds was evaluated in terms of mutagenicity, tumorigenicity, and reproductive effects. The drug-relevant properties (ClogP, drug-likeness, and drug score) were calculated, and the structure-activity relationship was discussed.