13659-23-9

Basic information

• Product Name: 2-Bromo-5-chlorophenol
• Synonyms: Phenol,2-broMo-5-chloro-
• CAS NO: 13659-23-9
• Molecular Formula: C₆H₄BrClO
• Molecular Weight: 207.46
• Product Categories: Heterocycles
• Mol File: 13659-23-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 222.158 °C at 760 mmHg
• Flash Point: 88.159 °C
• Appearance: /
• Density: 1.788 g/cm³
• Vapor Pressure: 0.069mmHg at 25°C
• Refractive Index: 1.619
• Storage Temp.: Keep Cold
• PKA: 7.47±0.10(Predicted)
• CAS DataBase Reference: 2-Bromo-5-chlorophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-5-chlorophenol(13659-23-9)
• EPA Substance Registry System: 2-Bromo-5-chlorophenol(13659-23-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 13659-23-9(Hazardous Substances Data)

Usage

Chemical Properties

Pale yellow crystalline powder

InChI:InChI=1/C6H4BrClO/c7-5-2-1-4(8)3-6(5)9/h1-3,9H

Upstream product

• 1193-72-2 1-bromo-2,4-dichlorobenzene 
• 124-41-4 sodium methylate 
• 823-57-4 2-bromo-5-chloroaniline 
• 108-43-0 3-monochlorophenol 
• 174913-09-8 2-bromo-5-chloroanisole 
• 41513-04-6 2-chloro-5-bromonitrobenzene 
• 255051-38-8 4-(4-chloro-2-(R,S)-methylsulfinylphenyl)piperidine 
• 16817-43-9 5-Bromo-2-chloroanisole 

Downstream Products

• 1056942-37-0 1-bromo-4-chloro-2-(difluoromethoxy)benzene 
• 1349866-01-8 6-chloro-2-(2-nitrophenyl)benzo[d]oxazole 
• 1009094-06-7 3-bromo-6-chloro-2-hydroxybenzaldehyde 
• 690261-59-7 1-bromo-4-chloro-2-[(phenylmethyl)-oxy]-benzene 
• 3380-34-5 triclosan 
• 1562338-42-4 5-(1H-pyrazol-4-yl)-2-(6-((2,2,6,6-tetramethylpiperidin-4-yl)oxy)pyridazin-3-yl)phenol 

Relevant articles and documents

Compounds and Methods for Inhibiting the Interaction of BCL Proteins with Binding Partners

The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.

Regioselective monobromination of substituted phenols in the presence of β-cyclodextrin

Cyclodextrin acts as a restricting nanovessel to enhance regioselectivity in bromination of substituted phenols such as 3-nitrophenol, 2-chlorophenol, 3-chlorophenol, and 4-chlorophenol. In contrast to solution bromination, cyclodextrin facilitates regioselective monobromination and formation of polybrominated products are substantially reduced. Selectivities in brominations are also observed in water and in the solid state. The observed results are rationalized on the basis of specific modes of inclusion of substituted phenols inside the cyclodextrin cavity and find strong support from energy minimization studies and 1H-1H NOESY.

N-SUBSTITUTED NAPHTHALENE CARBOXAMIDES AS NEUROKININ-RECEPTOR ANTAGONISTS

A compound of formula I wherein: R is alkyl; R1 is optionally substituted phenyl 2-oxo-tetrahydro-1(2H)-pyrimidinyl, or 2-oxo-1-piperidinyl; R2 is hydrogen, alkoxy, alkanoyloxy, alkoxycarbonyl, alkanoylamino, acyl, alkyl, carbamoyl, N-alkylcarbamoyl, N,N-dialkylcarbamoyl where the alkyl groups are the same or different, hydroxy, thioacyl, thiocarbamoyl, N-alkylthiocarbamoyl, or N,N-dialkylthiocarbamoyl where the alkyl groups are the same or different. X1 and X2 are independently hydrogen or halo, provided that at least one of X1 or X2 is halo; and R3, R4, R5 and R6 are independently hydrogen, cyano, nitro, trifluoromethoxy, trifluoromethyl, or alkylsulfonyl are antagonists of at least one tachykinin receptor and are useful in the treatment of depression, anxiety, asthma, pain, inflammation, urinary incontinence and other disease conditions. Process for their preparation are described, as are compositions containing them and their use.