1370455-90-5

Basic information

• Product Name: 4-({[2'-[4-(tert-butoxycarbonyl)piperazin-1-yl]-6-(pyrazin-2-ylamino)-2,4'-bipyridin-4-yl]amino}carbonyl)benzoic acid
• CAS NO: 1370455-90-5
• Molecular Weight: 596.646
• Mol File: 1370455-90-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-({[2'-[4-(tert-butoxycarbonyl)piperazin-1-yl]-6-(pyrazin-2-ylamino)-2,4'-bipyridin-4-yl]amino}carbonyl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-({[2'-[4-(tert-butoxycarbonyl)piperazin-1-yl]-6-(pyrazin-2-ylamino)-2,4'-bipyridin-4-yl]amino}carbonyl)benzoic acid(1370455-90-5)
• EPA Substance Registry System: 4-({[2'-[4-(tert-butoxycarbonyl)piperazin-1-yl]-6-(pyrazin-2-ylamino)-2,4'-bipyridin-4-yl]amino}carbonyl)benzoic acid(1370455-90-5)

Safety Data

• Hazardous Substances Data: 1370455-90-5(Hazardous Substances Data)

Upstream product

• 25194-01-8 4-nitro-2,6-dichloro-pyridine 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 128071-98-7 4-bromo-2-fluoropyridine 
• 1370455-89-2 tert-butyl 4-[4-{[4-(methoxycarbonyl)benzoyl]amino}-6-(pyrazin-2-ylamino)-2,4'-bipyridin-2'-yl]piperazine-1-carboxylate 
• 1370453-13-6 tert-butyl 4-[4-nitro-6-(pyrazin-2-ylamino)-2,4'-bipyridin-2'-yl]piperazine-1-carboxylate 
• 1370453-12-5 N-(6-chloro-4-nitropyridin-2-yl)pyrazin-2-amine 

Downstream Products

• 1370455-88-1 4-({[2'-piperazin-1-yl-6-(pyrazin-2-ylamino)-2,4'-bipyridin-4-yl]aminol}arbonyl)benzoic acid 

Relevant articles and documents

Highly potent aminopyridines as Syk kinase inhibitors

A novel class of potent Syk inhibitors has been developed from rational design. Highly potent aminopyridine derivatives bearing a 4-trifluoromethyl-2- pyridyl motif and represented by compound 13b IC50: 0.6 nM were identified. Substitution by a 2-pyrazinyl motif and SAR expansion in position 4 of the central core provided diverse potent non-cytotoxic Syk inhibitors showing nanomolar activity inhibiting human mast cell line LAD2 degranulation.