1370457-92-3Relevant articles and documents
Highly potent aminopyridines as Syk kinase inhibitors
Castillo, Marcos,Forns, Pilar,Erra, Montse,Mir, Marta,Lopez, Manel,Maldonado, Monica,Orellana, Adelina,Carreno, Cristina,Ramis, Isabel,Miralpeix, Montserrat,Vidal, Bernat
, p. 5419 - 5423 (2012/09/22)
A novel class of potent Syk inhibitors has been developed from rational design. Highly potent aminopyridine derivatives bearing a 4-trifluoromethyl-2- pyridyl motif and represented by compound 13b IC50: 0.6 nM were identified. Substitution by a 2-pyrazinyl motif and SAR expansion in position 4 of the central core provided diverse potent non-cytotoxic Syk inhibitors showing nanomolar activity inhibiting human mast cell line LAD2 degranulation.