1383714-46-2Relevant articles and documents
POLYCYCLIC AMIDES AS CYTOTOXIC AGENTS
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, (2020/03/29)
The invention relates to a compound of formula (I): or pharmaceutically acceptable salts, solvates, tautomers, stereoisomers or mixtures thereof; wherein the fused ring moiety is a non-alkylating moiety; and wherein the compounds are useful as medicaments, in particular for use as a drug in an antibody-drug conjugate and in the treatment of a proliferative disease, a bacterial infection, a malarial infection and inflammation.
GC-Targeted C8-linked pyrrolobenzodiazepine-biaryl conjugates with femtomolar in vitro cytotoxicity and in vivo antitumor activity in mouse models
Rahman, Khondaker M.,Jackson, Paul J. M.,James, Colin H.,Basu, B. Piku,Hartley, John A.,De La Fuente, Maria,Schatzlein, Andreas,Robson, Mathew,Pedley, R. Barbara,Pepper, Chris,Fox, Keith R.,Howard, Philip W.,Thurston, David E.
, p. 2911 - 2935 (2013/05/23)
DNA binding 4-(1-methyl-1H-pyrrol-3-yl)benzenamine (MPB) building blocks have been developed that span two DNA base pairs with a strong preference for GC-rich DNA. They have been conjugated to a pyrrolo[2,1-c][1,4]benzodiazepine (PBD) molecule to produce