138665-22-2

Basic information

• Product Name: (2R,3R)-3-phenyl-3-(benzylamino)propanediol
• Synonyms: (2R,3R)-3-phenyl-3-(benzylamino)propanediol
• CAS NO: 138665-22-2
• Molecular Weight: 257.332
• Mol File: 138665-22-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (2R,3R)-3-phenyl-3-(benzylamino)propanediol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R)-3-phenyl-3-(benzylamino)propanediol(138665-22-2)
• EPA Substance Registry System: (2R,3R)-3-phenyl-3-(benzylamino)propanediol(138665-22-2)

Safety Data

• Hazardous Substances Data: 138665-22-2(Hazardous Substances Data)

Upstream product

• 21915-53-7 2,3-epoxy-3-phenyl-1-propanol 
• 100-46-9 benzylamine 
• 40641-81-4 trans-2,3-epoxy-3-phenylpropan-1-ol 
• 104196-23-8 (2S,3S)-2,3-epoxy-3-phenyl-1-propanol 
• 1134-97-0 2-carbamoyloxymethyl-3-phenyl-oxirane 

Downstream Products

• 201055-40-5 Carbonic acid 1-[(R)-(benzyl-tert-butoxycarbonyl-amino)-phenyl-methyl]-allyl ester ethyl ester 

Relevant articles and documents

Highly regioselective ring-opening of epoxides with amines: A metal- A nd solvent-free protocol for the synthesis of β-amino alcohols

We herein report a metal- A nd solvent-free acetic acid-mediated ring-opening reaction of epoxides with amines. This process provides β-amino alcohols in high yields with excellent regioselectivity. Importantly, this epoxide ring-opening protocol can be used for the introduction of amines in natural products during late-stage transformations.

Synthesis of chiral allyltitaniums having an amino group at the C-4 position and their diastereoselective addition reaction with aldehydes

Chiral allyltitaniums having an amino substituent at the C-4 position are prepared from optically active allylic alcohol derivatives 1 and Ti(O-i-Pr)4/2i-PrMgCl reagent, which, in turn, react with aldehydes regio- and stereoselectively to afford 3-amino-2-vinylalkanols in excellent yields.