1397-94-0

Basic information

• Product Name: ANTIMYCIN A
• Synonyms: antimycina,mixtureofthecomponentsa(1),a(2),a(3),a(4);antipiricullin;antipricullin[qr];caswellno052b[qr];epapesticidechemicalcode006314[qr];verosin[qr];virosin;virosin[qr]
• CAS NO: 1397-94-0
• Molecular Formula: C28H40N2O9
• Molecular Weight: 548.6252
• Product Categories: Antibiotics;Antibiotics A to;Antibiotics A-FAntibiotics;Antibiotics by Application;AntifungalAntibiotics;Antineoplastic and Immunosuppressive AntibioticsAntibiotics;Chemical Structure Class;Inhibits an EnzymeAntibiotics;Mechanism of Action;Peptides;Spectrum of Activity;Cell Stress;Inhibits an EnzymeNitric Oxide and Cell Stress;Mitochondrial InhibitorsAntibiotics;PeptidesMore...Close...
• Mol File: 1397-94-0.mol
• Article Data: 0

Chemical Properties

• Melting Point: 141-142℃
• Boiling Point: 598.78°C (rough estimate)
• Flash Point: 412.1°C
• Appearance: /
• Density: 1.6009 (rough estimate)
• Vapor Pressure: 8.94E-24mmHg at 25°C
• Refractive Index: 1.5800 (estimate)
• Storage Temp.: 2-8°C
• Water Solubility: Soluble in 100% ethanol. Insoluble in water.
• Sensitive: Light Sensitive
• CAS DataBase Reference: ANTIMYCIN A(CAS DataBase Reference)
• NIST Chemistry Reference: ANTIMYCIN A(1397-94-0)
• EPA Substance Registry System: ANTIMYCIN A(1397-94-0)

Safety Data

• Hazard Codes: T,N
• Statements: 25-50
• Safety Statements: 26-36/37/39-45-61
• RIDADR: UN 3462 6.1/PG 2
• WGK Germany: 3
• RTECS: CD0350000
• F: 18
• HazardClass: 6.1(a)
• PackingGroup: II
• Hazardous Substances Data: 1397-94-0(Hazardous Substances Data)

Usage

Description

Antimycin A is a complex of related macrocyclic lactones, predominantly A1 to A4, isolated from several species of Streptomyces. It is a crystalline solid with potent antifungal activity and is known for its ability to bind to cytochrome C reductase at the Qi site, inhibiting the oxidation of ubiquinol to ubiquinone. Antimycin A has over 20 known analogues and is widely used as a bioprobe of respiration.

Uses

Used in Antifungal Applications:
Antimycin A is used as an antifungal agent for its potent antifungal activity, particularly against various fungal species. It is effective in controlling fungal infections and is registered as a pesticide in the U.S.
Used in Agricultural Industry:
Antimycin A is used as a fungicide, piscicide, and potentially as an insecticide and miticide in the agricultural industry. As a U.S. EPA restricted Use Pesticide (RUP), it plays a crucial role in controlling pests and maintaining crop health.
Used in Biochemical Research:
Antimycin A is used as a bioprobe of respiration in biochemical research. It helps scientists study the specific sites of reactive oxygen species production in mitochondria and their relationship with local oxidative stress induced by exercise.
Used in Pharmaceutical Industry:
Antimycin A is used in the pharmaceutical industry for its antiviral properties and its ability to interfere with cytochrome oxidation. It has potential applications in the development of new drugs targeting viral infections and other related conditions.

Fire Hazard

When heated to decomposition, ANTIMYCIN A emits toxic fumes of oxides of nitrogen.

Trade name

FINTROL?; VIROSIN?

Safety Profile

Poison by ingestion,intraperitoneal, subcutaneous, and intravenous routes.When heated to decomposition it emits toxic fumes ofNOx.

Potential Exposure

Specific uses for antimycin A were not found, however, antimycin A1, and antimycin A3 are reported to be antibiotic substances produced by streptomyces for use as a fungicide, possible insecticide and miticide. Registered as a pesticide in the U.S.

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

InChI:InChI=1/C28H40N2O9/c1-6-7-8-9-11-20-25(39-22(32)14-16(2)3)18(5)38-28(36)23(17(4)37-27(20)35)30-26(34)19-12-10-13-21(24(19)33)29-15-31/h10,12-13,15-18,20,23,25,33H,6-9,11,14H2,1-5H3,(H,29,31)(H,30,34)/t17-,18+,20-,23?,25+/m1/s1

Related news

ANTIMYCIN A (cas 1397-94-0) induces apoptosis in As4.1 juxtaglomerular cells09/06/2019

Antimycin A, an inhibitor of electron transport in mitochondria, has been used as reactive oxygen species (ROS) generator in the biological system. Here, we investigated the in vitro effect of antimycin A on apoptosis in As4.1 juxtaglomerular cells. Antimycin A efficiently induced apoptosis in A...detailed

Mitochondrial defects and cytotoxicity by ANTIMYCIN A (cas 1397-94-0) on cultured osteoblastic MC3T3-E1 cells09/05/2019

Antimycin A (AMA), which inhibits complex III of the electron transport system, has been used as a reactive oxygen species (ROS) generator in biological systems. We investigated the effects of AMA on various parameters related to mitochondrial function in osteoblastic MC3T3-E1 cells. Here, we sh...detailed

Full Length ArticleLiposomes containing cholesterol and mitochondria-penetrating peptide (MPP) for targeted delivery of ANTIMYCIN A (cas 1397-94-0) to A549 cells09/03/2019

•Mitochondria are exclusively employed to produce energy required for the vital metabolic functions of the cell. However, mitochondria also play a key role in mammalian cell death. Dissipation in the mitochondria membrane potential causes cell death. Therefore, in cancer therapy, mitochondria ar...detailed

Streptomyces strains producing mitochondriotoxic ANTIMYCIN A (cas 1397-94-0) found in cereal grains09/02/2019

Reasons for mammalian cell toxicity observed in barley and spring wheat grains were sought. Streptomyces sp. isolates from wheat and barley produced heat-stable methanol-soluble substances which inhibited the motility of exposed porcine spermatozoa used as a toxicity indicator. Several barley is...detailed