139706-47-1

Basic information

• Product Name: Benzenemethanol, 4-[[[tris(1-methylethyl)silyl]oxy]methyl]-
• CAS NO: 139706-47-1
• Molecular Formula: C17H30O2Si
• Molecular Weight: 294.51
• Mol File: 139706-47-1.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 4-[[[tris(1-methylethyl)silyl]oxy]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 4-[[[tris(1-methylethyl)silyl]oxy]methyl]-(139706-47-1)
• EPA Substance Registry System: Benzenemethanol, 4-[[[tris(1-methylethyl)silyl]oxy]methyl]-(139706-47-1)

Safety Data

• Hazardous Substances Data: 139706-47-1(Hazardous Substances Data)

Usage

Functional Group

Tris(1-methylethyl)silyl group attached to the hydroxyl group of benzenemethanol

Common Use

Synthesis of pharmaceuticals and organic molecules

Hydroxyl Group Protection

Useful for protecting hydroxyl groups in organic synthesis

Removal Conditions

Can be easily removed under mild conditions

Reagent Use

Employed as a reagent in organic synthesis

Building Block

Acts as a building block in the production of complex organic molecules

Upstream product

• 1174669-43-2 1-(triethylsilyloxymethyl)-4-(triisopropylsilyloxymethyl)benzene 
• 139706-48-2 4-(tert-butyldimethylsilyloxymethyl)benzoic acid methyl ester 
• 13154-24-0 triisopropylsilyl chloride 
• 589-29-7 p-xylylene glycol 
• 139706-46-0 4-<(tert-butyldimethylsiloxy)methyl><(triisopropylsiloxy)methyl>benzene 

Downstream Products

• 1174669-43-2 1-(triethylsilyloxymethyl)-4-(triisopropylsilyloxymethyl)benzene 
• 313279-17-3 2-(4-triisopropylsilanyloxymethyl-phenyl)-1H-benzoimidazole-4-carboxylic acid amide 
• 313279-20-8 2-[4-(hydroxymethyl)phenyl]-1H-benzimidazole-4-carboxamide 
• 934667-50-2 2-(4-(triisopropylsiloxymethyl)phenyl)-5-(4-(methoxymethyl)phenyl)-3,4-bis-(4-bromophenyl)cyclopenta-2,4-dienone 
• 934667-49-9 2-(4-(triisopropylsiloxymethyl)phenyl)-5-(4-(methoxymethyl)phenyl)-3,4-diphenylcyclopenta-2,4-dienone 
• 934667-43-3 1-(4-(triisopropylsilanyloxymethyl)phenyl)-3-(4-methoxymethylphenyl)-propan-2-one 
• 934667-40-0 1,3-bis-(4-(triisopropylsilanyloxymethyl)phenyl)-propan-2-one 
• 934667-38-6 ((4-(bromomethyl)benzyl)oxy)triisopropylsilane 
• 313279-15-1 4-((triisopropylsilyloxy)methyl)benzaldehyde 

Relevant articles and documents

Hafnium Triflate as a Highly Potent Catalyst for Regio- and Chemoselective Deprotection of Silyl Ethers

As a Group IVB transition metal Lewis acid, hafnium triflate [Hf(OTf) 4 ] exhibited exceptionally high potency in desilylations. Since the amounts of Hf(OTf) 4 required for the deprotection of 1°, 2°, 3° alkyl and aryl tert -butyldimethylsilyl (TBS) ethers are significantly different, ranging from 0.05 mol% to 3 mol%, regioselective deprotection of TBS could be easily implemented. Moreover, chemoselective cleavage of different silyl ethers or removal of TBS in the presence of most hydroxyl protecting groups was also accomplished. NMR analyses of silyl products from TBS deprotection indicated that Hf(OTf) 4 -catalyzed desilylation may proceed via different mechanisms, depending on the solvent used.

NOVEL CRYPTOPHYCIN COMPOUNDS AND CONJUGATES, THEIR PREPARATION AND THEIR THERAPEUTIC USE

The present invention relates to cryptophycin compounds of formula (I). The invention also relates to cryptophycin payloads, to cryptophycin conjugates, to compositions containing them and to their therapeutic use, especially as anticancer agents. The inv

Fluorous TBAF: A convenient and selective reagent for fluoride-mediated deprotections

(Chemical Equation Presented) A fluorous analogue of TBAF has been developed for its use in the clean removal of silicon-derived protecting groups. Purification of the crude mixtures by fluorous solid-phase extractions allowed alcohols, amines, and carboxylic acids to be obtained in high purity, with no need of chromatographic separations. The moderate reactivity of fluorous TBAF was exploited in selective deprotections of several bifunctional molecules.