1402070-25-0Relevant articles and documents
Synthesis of cephalosporin-3′-diazeniumdiolates: Biofilm dispersing NO-donor prodrugs activated by β-lactamase
Yepuri, Nageshwar Rao,Barraud, Nicolas,Mohammadi, Nasim Shah,Kardak, Bharat G.,Kjelleberg, Staffan,Rice, Scott A.,Kelso, Michael J.
, p. 4791 - 4793 (2013/06/27)
Use of biofilm dispersing NO-donor compounds in combination with antibiotics has emerged as a promising new strategy for treating drug-resistant bacterial biofilm infections. This paper details the synthesis and preliminary evaluation of six cephalosporin
Cephalosporin-3'-diazeniumdiolates: Targeted NO-donor prodrugs for dispersing bacterial biofilms
Barraud, Nicolas,Kardak, Bharat G.,Yepuri, Nageshwar R.,Howlin, Robert P.,Webb, Jeremy S.,Faust, Saul N.,Kjelleberg, Staffan,Rice, Scott A.,Kelso, Michael J.
, p. 9057 - 9060 (2012/10/29)
Just say NO to biofilms: NO-donors are used to disperse a bacterial biofilm so that co-administered antibiotics will kill the more susceptible unattached cells. The chemically stable cephalosporin-3'-diazeniumdiolate NO-donor prodrug (see scheme) is activated by bacterial β-lactamases and facilitates this two-step biofilm erradication. Copyright
