1421060-63-0

Basic information

• Product Name: 1-(dodecane-1-sulfonyl)-4-methyl[1,4]diazepane
• Synonyms: 1-(dodecane-1-sulfonyl)-4-methyl[1,4]diazepane
• CAS NO: 1421060-63-0
• Molecular Weight: 346.578
• Mol File: 1421060-63-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(dodecane-1-sulfonyl)-4-methyl[1,4]diazepane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(dodecane-1-sulfonyl)-4-methyl[1,4]diazepane(1421060-63-0)
• EPA Substance Registry System: 1-(dodecane-1-sulfonyl)-4-methyl[1,4]diazepane(1421060-63-0)

Safety Data

• Hazardous Substances Data: 1421060-63-0(Hazardous Substances Data)

Upstream product

• 4318-37-0 1-Methylhomopiperazine 
• 10147-40-7 1-Dodecanesulfonyl chloride 

Relevant articles and documents

Design, synthesis and biological evaluation of novel aliphatic amido/sulfonamido-quaternary ammonium salts as antitumor agents

RhoB, one of the upstream signaling proteins of the phosphatidylinositol-3- kinase (PI3K)/Akt pathway, is frequently mutated in human cancer. Based on a piperazine alkyl derivative that induced apoptosis via up-regulation of RhoB, we synthesized novel aliphatic amido/sulfonamido-quaternary ammonium salts and evaluated their biological activities using an in vitro growth inhibition assay and RhoB promoter assay in human cancer cells. Compound 3a was the most promising anticancer agent in the series, based upon its potent growth inhibition via RhoB-mediated signaling. These novel aliphatic amido/sulfonamido-quaternary ammonium salts may be useful as a platform for development of anticancer chemotherapeutic agents.