1421583-10-9

Basic information

• Product Name: C₁₇H₂₂N₆O
• CAS NO: 1421583-10-9
• Molecular Weight: 326.401
• Mol File: 1421583-10-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₂₂N₆O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₂₂N₆O(1421583-10-9)
• EPA Substance Registry System: C₁₇H₂₂N₆O(1421583-10-9)

Safety Data

• Hazardous Substances Data: 1421583-10-9(Hazardous Substances Data)

Upstream product

• 5463-09-2 6-amino-2-butylamino-9H-purine 
• 16473-35-1 4-(hydroxymethyl)benzyl chloride 

Downstream Products

• 1421583-11-0 C₁₇H₂₁BrN₆O 

Relevant articles and documents

Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility

We report the discovery of novel series of highly potent TLR7 agonists based on 8-oxoadenines, 1 and 2 by introducing and optimizing various tertiary amines onto the N(9)-position of the adenine moiety. The introduction of the amino group resulted in not only improved water solubility but also enhanced TLR7 agonistic activity. In particular compound 20 (DSR-6434) indicated an optimal balance between the agonistic potency and high water solubility. It also demonstrated a strong antitumor effect in vivo by intravenous administration in a tumor bearing mice model.