1429328-18-6

Basic information

• Product Name: (E)-2-(3,5-dimethoxystyryl)-3,4-dihydro-2H-pyran
• CAS NO: 1429328-18-6
• Molecular Weight: 246.306
• Mol File: 1429328-18-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-2-(3,5-dimethoxystyryl)-3,4-dihydro-2H-pyran(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-(3,5-dimethoxystyryl)-3,4-dihydro-2H-pyran(1429328-18-6)
• EPA Substance Registry System: (E)-2-(3,5-dimethoxystyryl)-3,4-dihydro-2H-pyran(1429328-18-6)

Safety Data

• Hazardous Substances Data: 1429328-18-6(Hazardous Substances Data)

Upstream product

• 3749-36-8 2-hydroxymethyl-3,4-dihydro-2H-pyran 
• 877-88-3 3,5-dimethoxybenzyl bromide 
• 100-73-2 acrolein dimer 
• 24131-30-4 (3,5-dimethoxybenzyl)triphenylphosphonium bromide 

Downstream Products

• 1380294-08-5 (E)-6-(3,5-dimethoxystyryl)-5,6-dihydro-2H-pyran-2-one 

Relevant articles and documents

Design, synthesis, in vitro cytotoxicity evaluation and structure-activity relationship of Goniothalamin analogs

A series of six/five member (E/Z)-Goniothalamin analogs were synthesized from commercially available (3,4-dihydro-2H-pyran-2-yl)methanol/5- (hydroxymethyl)dihydrofuran-2(3H)-one in three steps with good to moderate overall yields and their cytotoxicity against lymphoblastic leukemic T cell line (Jurkat E6.1) have been evaluated. Among the synthesized analogs, (Z)-Goniothalamin appeared to be the most active in cytotoxicity (IC 50 = 12 μM). Structure-activity relationship study indicates that introducing substituent in phenyl ring or replacing phenyl ring by pyridine/naphthalene, or decreasing the ring size of lactones (from six to five member) do not increase the cytotoxicity.