143746-13-8

Basic information

• Product Name: 2-(N,N-Dibenzylamino)ethyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate
• Synonyms: 2-(N,N-Dibenzylamino)ethyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate
• CAS NO: 143746-13-8
• Molecular Weight: 396.53
• Mol File: 143746-13-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(N,N-Dibenzylamino)ethyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(N,N-Dibenzylamino)ethyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate(143746-13-8)
• EPA Substance Registry System: 2-(N,N-Dibenzylamino)ethyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate(143746-13-8)

Safety Data

• Hazardous Substances Data: 143746-13-8(Hazardous Substances Data)

Upstream product

• 101-06-4 N,N-dibenzyl-2-aminoethanol 
• 146176-60-5 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonyl chloride 
• 100-44-7 benzyl chloride 

Downstream Products

• 1027418-93-4 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (R)-1-carboxy-2-dibenzylamino-ethyl ester 
• 143837-93-8 (R)-3-(N,N-Dibenzylamino)propane-1,2-diol 
• 143746-19-4 methyl (R)-(-)-3-(N,N-dibenzylamino)-2-[(2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonyl)oxy]propanoate 
• 143746-16-1 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-1-methyl-ethyl ester 
• 143746-17-2 (S)-(+)-[2-(N,N-Dibenzylamino)-1-trimethylsilylethyl] 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate 

Relevant articles and documents

Stereoselective deprotonation of chiral and achiral 2-aminoalkyl carbamates: Synthesis of optically active β-amino alcohols via 1-oxy- substituted alkyllithium intermediates

A facile protocol for the electrophilic C-substitution (methylation, acylation, α-hydroxyalkylation, and carboxylation) of several 2-(N,N- dibenzylamino)alkan-1-ols via the carbamates 10 is reported. The stereochemistry of the lithiation is greatly influenced by the complexing diamine. The substrate-directed selection between the diastereotopic a-pro-R and pro-S protons in the TMEDA-assisted deprotonation is largely shifted towards pro-S-selectivity in the presence of (-)-sparteine (4). Each of both diastereomeric series is readily accessible in several cases.