14438-63-2

Basic information

• Product Name: 1-(2,5-dimethoxyphenyl)-2-nitroethanol
• Synonyms: 1-(2,5-dimethoxyphenyl)-2-nitroethanol
• CAS NO: 14438-63-2
• Molecular Weight: 227.217
• Mol File: 14438-63-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1-(2,5-dimethoxyphenyl)-2-nitroethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,5-dimethoxyphenyl)-2-nitroethanol(14438-63-2)
• EPA Substance Registry System: 1-(2,5-dimethoxyphenyl)-2-nitroethanol(14438-63-2)

Safety Data

• Hazardous Substances Data: 14438-63-2(Hazardous Substances Data)

Usage

Structure

Nitroethanol derivative with a phenyl ring, methoxy substituents, and a nitro group attached to a two-carbon ethyl chain

Usage

Intermediate in the synthesis of various pharmaceuticals and organic compounds

Biological activities

Potential vasodilator and use in the treatment of cardiovascular diseases

Safety precautions

Proper handling and safety measures should be taken to prevent potential hazards

Upstream product

• 75-52-5 nitromethane 
• 93-02-7 2,5-dimethoxybenzaldehyde 

Downstream Products

• 919797-20-9 2-(((4-iodo-2,5-dimethoxyphenethyl)amino)methyl)phenol 
• 108536-18-1 β-dimethoxy-2,5 phenyl nitro ethylene 
• 1335017-70-3 (1R)-1-(2,5-dimethoxyphenyl)-2-nitroethanol 
• 93-02-7 2,5-dimethoxybenzaldehyde 
• 3600-87-1 desglymidodrine 
• 14547-37-6 1-(2,5-dimethoxy-phenyl)-3-morpholin-4-yl-2-nitro-propan-1-one 
• 14367-89-6 1-(2,5-dimethoxy-phenyl)-2-nitro-ethanone 

Relevant articles and documents

Synthesis of 25X-BOMes and 25X-NBOHs (X = H, I, Br) for pharmacological studies and as reference standards for forensic purposes

An expeditious method is reported for the synthesis of three NBOHs (25H-, 25I- and 25B-NBOH; 9–38% overall yield) and three NBOMes (25H-, 25I- and 25B-NBOMe; 7–33% overall yield) from salicylaldehyde and 2-methoxyaldehyde, respectively. The X-ray structures of 25H-, 25I- and 25B-NBOH.HCl were also determined. Our approach should provide a general entry for preparing such a class of substances for pharmacological and forensic purposes.

Salen-Based Covalent Organic Framework

The Salen unit represents one of the most important ligands in coordination chemistry. We report herein the first example of a Salen-based covalent organic framework (COF), in which both the construction of the COF structure and the functionalization with Salen moieties have been realized in a single step. Due to its structural uniqueness, the obtained COF material, Salen-COF, possesses high crystallinity and excellent stability. Based on this, a series of metallo-Salen-based COFs were prepared via metalation for further applications.

(2S,5R)-2-Methylaminomethyl-1-methyl-5-phenylpyrrolidine, a chiral diamine ligand for copper(ii)-catalysed Henry reactions with superb enantiocontrol

A cis-2-aminomethyl-5-phenylpyrrolidine, which is easily available from methyl Boc-l-pyroglutamate, was found to be a highly efficient chiral ligand for Cu(ii)-catalysed Henry reactions. Excellent yields (>90%) and superb levels of enantiocontrol (98.5-99.6% ee) were reached with aromatic, heteroaromatic, vinylic, and aliphatic aldehydes (36 examples). This journal is the Partner Organisations 2014.