1451149-95-3

Basic information

• Product Name: 5-[(1E,3E)-4-(1,3-benzodioxol-5-yl)buta-1,3-dien-1-yl]-4-ethyl-2,4-dihydro-3H-1,2,4-triazole-3-thione
• CAS NO: 1451149-95-3
• Molecular Weight: 301.369
• Mol File: 1451149-95-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-[(1E,3E)-4-(1,3-benzodioxol-5-yl)buta-1,3-dien-1-yl]-4-ethyl-2,4-dihydro-3H-1,2,4-triazole-3-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(1E,3E)-4-(1,3-benzodioxol-5-yl)buta-1,3-dien-1-yl]-4-ethyl-2,4-dihydro-3H-1,2,4-triazole-3-thione(1451149-95-3)
• EPA Substance Registry System: 5-[(1E,3E)-4-(1,3-benzodioxol-5-yl)buta-1,3-dien-1-yl]-4-ethyl-2,4-dihydro-3H-1,2,4-triazole-3-thione(1451149-95-3)

Safety Data

• Hazardous Substances Data: 1451149-95-3(Hazardous Substances Data)

Upstream product

• 1451149-80-6 (2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)penta-2,4-dienehydrazide 
• 136-72-1 piperic acid 
• 94-62-2 Piperine 
• 1451149-82-8 2-[(2E,4E)-5-(1,3-benzodioxol-5-yl)penta-2,4-dienoyl]-N-ethylhydrazinecarbothioamide 
• 4711-72-2 piperic acid chloride 

Relevant articles and documents

Design, synthesis and trypanocidal evaluation of novel 1,2,4-triazoles-3- thiones derived from natural piperine

The work reported herein describes the synthesis and the assessment of the trypanocidal activity of thirteen new 1,2,4-triazole-3-thiones obtained from natural piperine, the main constituent of the dry fruits of Piper nigrum. It is part of a research program aiming to use abundant and easily available natural products as starting materials for the design and synthesis of new molecules potentially useful as antiparasitic drugs. The variously substituted triazole derivatives were synthesized from the natural amide in four steps with the use of microwave irradiation on overall yields ranging from 32% to 51%. The cyclohexyl substituted derivative showed the best trypanocidal profile on proliferative forms of Trypanosoma cruzi (Y strain), with IC50s = 18.3 and 8.87 μM against epimastigotes and amastigotes, respectively.