145285-56-9

Basic information

• Product Name: (E)-ethyl 6-phenylhex-4-enoate
• Synonyms: (E)-ethyl 6-phenylhex-4-enoate
• CAS NO: 145285-56-9
• Molecular Weight: 218.296
• Mol File: 145285-56-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (E)-ethyl 6-phenylhex-4-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-ethyl 6-phenylhex-4-enoate(145285-56-9)
• EPA Substance Registry System: (E)-ethyl 6-phenylhex-4-enoate(145285-56-9)

Safety Data

• Hazardous Substances Data: 145285-56-9(Hazardous Substances Data)

Upstream product

• 105-36-2 ethyl bromoacetate 
• 106-99-0 buta-1,3-diene 
• 98-80-6 phenylboronic acid 
• 122-78-1 phenylacetaldehyde 
• 82819-46-3 (E)-diethyl 2-(4-phenylbut-2-en-1-yl)malonate 
• 6052-66-0 1-phenyl-3-buten-2-ol 
• 78-39-7 Triethyl orthoacetate 

Downstream Products

• 125225-52-7 (5S,1'S)-5-(1'-hydroxy-2'-phenylethyl)dihydrofuran-2(3H)-one 
• 125225-54-9 (4R,5R)-5-hydroxy-6-phenyl-4-hexanolide 
• 145761-24-6 Methanesulfonic acid (R)-1-((R)-5-oxo-tetrahydro-furan-2-yl)-2-phenyl-ethyl ester 
• 135130-98-2 (4R)-4-{1-[(S)-(tert-butoxycarbonyl)amino]-2-phenylethyl}-γ-butyrolactone 
• 144141-82-2 (2S,4S,5S)-2,5-bis<<(1,1-dimethylethoxy)carbonyl>amino>-1,6-diphenyl-4-hydroxyhexane 
• 98818-40-7 (4R,5S)-3-benzyl-5-{(1S)-1-[(tert-butoxycarbonyl)amino]-2-phenylethyl}dihydrofuran-2-(3H)-one 
• 144163-44-0 (2S,3S,5S)-3-hydroxy-2,5-bisamino-1,6-diphenylhexane 
• 98737-45-2 (2S,4R,5S)-2-Benzyl-5-tert-butoxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-6-phenyl-hexanoic acid 
• 331767-03-4 tert-butyl (1S,2R,4S)-4-amino-1-benzyl-2-hydroxy-5-phenylpentylcarbamate 
• 82819-48-5 (E)-6-phenylhex-4-enoic acid 

Relevant articles and documents

Asymmetric dihydroxylation route to a dipeptide isostere of a protease inhibitor: Enantioselective synthesis of the core unit of ritonavir

An enantioselective synthesis of the dipeptide isostere of ritonavir has been accomplished utilizing Sharpless asymmetric hydroxylation as the key step.

NiH-Catalyzed Proximal-Selective Hydroamination of Unactivated Alkenes

Reported herein is a modular, NiH-catalyzed system capable of proximal-selective hydroamination of unactivated alkenes with diverse amine sources. The key to the successful implementation of this approach is the promotion of NiH insertion into even highly substituted olefins via coordination of the bidentate directing group to the nickel complex. A wide range of primary and secondary amines can be installed in both internal and terminal unactivated alkenes with excellent regiocontrol under the optimized reaction conditions. This protocol is flexible and general for the preparation of a variety of valuable β- and γ-amino acid building blocks that would otherwise be difficult to synthesize. The utility of this transformation was further demonstrated by the site-selective late-stage modification of complex and medicinally relevant molecules. Combined experimental and computational studies illuminate the detailed reaction mechanism.

Ring-Opening of Vinylcyclopropane-1,1-dicarboxylates by Boronic Acids under Ligandless Palladium Catalysis in Neat Water

We report a highly efficient ring-opening reaction of vinylcyclopropanes by boronic acids in water, using palladium nanoparticles formed from Pd(OAc)2 under ligandless conditions. Unsubstituted vinylcyclopropanes provide linear addition products with high selectivity, while a switch in regioselectivity to branched products is observed for aryl-substituted vinylcyclopropanes.