147081-44-5 Usage
Description
(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine, also known as (S)-(-)-1-Boc-3-aminopyrrolidine, is a colorless to light yellow liquid with specific chemical properties. It is an organic compound that plays a significant role in the synthesis of various pharmaceutical compounds due to its unique structure and reactivity.
Uses
Used in Pharmaceutical Industry:
(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine is used as an intermediate compound for the synthesis of various pharmaceutical agents. Its application is primarily due to its ability to be incorporated into the structure of complex molecules, enhancing their therapeutic properties.
1. Descarboxamide Analog Synthesis:
(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine is used as a key intermediate in the synthesis of the descarboxamide analog of 4-N-(Nω-nitro-L-argininyl)-trans-4-amino-L-proline amide. This analog has potential applications in the development of new drugs targeting specific biological pathways.
2. Histamine 3 (H3) Receptor Antagonists:
In the field of medicinal chemistry, (S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine is utilized in the development of Histamine 3 (H3) receptor antagonists containing the pyrrolidin-3-yl-N-methylbenzamide moiety. These antagonists are crucial in the treatment of various central nervous system disorders, such as cognitive impairment, attention deficit hyperactivity disorder (ADHD), and Alzheimer's disease, by modulating the histaminergic system.
Check Digit Verification of cas no
The CAS Registry Mumber 147081-44-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,7,0,8 and 1 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 147081-44:
(8*1)+(7*4)+(6*7)+(5*0)+(4*8)+(3*1)+(2*4)+(1*4)=125
125 % 10 = 5
So 147081-44-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H18N2O2/c1-9(2,3)13-8(12)11-5-4-7(10)6-11/h7H,4-6,10H2,1-3H3/t7-/m0/s1
147081-44-5Relevant articles and documents
The identification and use of robust transaminases from a domestic drain metagenome
Leipold, Leona,Dobrijevic, Dragana,Jeffries, Jack W.E.,Bawn, Maria,Moody, Thomas S.,Ward, John M.,Hailes, Helen C.
, p. 75 - 86 (2019/01/11)
Transaminases remain one of the most promising biocatalysts for use in chiral amine synthesis, however their industrial implementation has been hampered by their general instability towards, for example, high amine donor concentrations and organic solvent content. Herein we describe the identification, cloning and screening of 29 novel transaminases from a household drain metagenome. The most promising enzymes were fully characterised and the effects of pH, temperature, amine donor concentration and co-solvent determined. Several enzymes demonstrated good substrate tolerance as well as an unprecedented robustness for a wild-type transaminase. One enzyme in particular readily accepted IPA as an amine donor giving the same conversion with 2-50 equivalents, as well as being tolerant to a number of co-solvents, and operational in up to 50% DMSO-a characteristic as yet unobserved in a wild-type transaminase. This work highlights the value of using metagenomics for biocatalyst discovery from niche environments, and here has led to the identification of one of the most robust native transaminases described to date, with respect to IPA and DMSO tolerance.
HETEROAROMATIC DERIVATIVES AND PHARMACEUTICAL APPLICATIONS THEREOF
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, (2016/05/02)
Disclosed are heteroaryl derivatives, pharmaceutical composition and uses in the manufacture of a medicine for treating respiratory diseases, especially for chronic obstructive pulmonary disease (COPD).
Connecting Unexplored Protein Crystal Structures to Enzymatic Function
Steffen-Munsberg, Fabian,Vickers, Clare,Thontowi, Ahmad,Schaetzle, Sebastian,Tumlirsch, Tony,SvedendahlHumble, Maria,Land, Henrik,Berglund, Per,Bornscheuer, Uwe T.,Hoehne, Matthias
, p. 150 - 153 (2013/03/13)
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