1471-18-7Relevant articles and documents
Cluster mannosides as inhibitors of type 1 fimbriae-mediated adhesion of Escherichia coli: Pentaerythritol derivatives as scaffolds
Lindhorst, Thisbe K.,Dubber, Michael,Krallmann-Wenzel, Ulrike,Ehlers, Stefan
, p. 2027 - 2034 (2000)
Pentaerythritol derivatives were used as core molecules for the synthesis of two cluster α-D-mannosides, which were designed as oligomannoside mimetics. The problem of glycosyl orthoester formation, which frequently occurs in oligo-mannosylations, was solved. The clusters were tested for their capacity to block binding of Escherichia coli to yeast mannan in vitro and were found to be more than 200 times more potent in inhibiting mannose-specific adhesion than methyl α-D-mannoside.
The effect of polyglycerol sulfate branching on inflammatory processes
Paulus, Florian,Schulze, Ronny,Steinhilber, Dirk,Zieringer, Maximilian,Steinke, Ingo,Welker, Pia,Licha, Kai,Wedepohl, Stefanie,Dernedde, Jens,Haag, Rainer
, p. 643 - 654 (2014)
In this study, the extent to which the scaffold architecture of polyglycerol sulfates affects inflammatory processes and hemocompatibility is investigated. Competitive L-selectin binding assays, cellular uptake studies, and blood compatibility readouts are done to evaluate distinct biological properties. Fully glycerol based hyperbranched polyglycerol architectures are obtained by either homopolymerization of glycidol (60% branching) or a new copolymerization strategy of glycidol with ethoxyethyl glycidyl ether. Two polyglycerols with 24 and 42% degree of branching (DB) are synthesized by using different monomer feed ratios. A perfectly branched polyglycerol dendrimer is synthesized according to an iterative two-step protocol based on allylation of the alcohol and subsequent catalytic dihydroxylation. All the polyglycerol sulfates are synthesized with a comparable molecular weight and degree of sulfation. The DB make the different polymer conjugates perform different ways. The optimal DB is 60% in all biological assays.
Preparation method of pentaerythritol triallyl ether
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Paragraph 0036-0052, (2020/06/16)
The invention provides a preparation method of pentaerythritol triallyl ether and particularly relates to the technical field of synthesis of pentaerythritol triallyl ether. The method is characterized by comprising the following steps: S1, under normal pressure, feeding pentaerythritol, pentaerythritol triallyl ether, tetrabutylammonium bromide and 50% sodium hydroxide aqueous solution into a stirring reaction kettle, and heating the mixture to dissolve pentaerythritol into liquid; S2, dropwise adding chloropropene, keeping chloropropene and water evaporated, and layering the chloropropene and water after condensation, and returning chloropropene to the stirring reaction kettle; and S3, after the reaction is finished, adding water, and cooling and standing the mixture for layering, and carrying out reduced pressure distillation on the upper organic phase to obtain the product pentaerythritol triallyl ether. According to the preparation method of pentaerythritol triallyl ether providedby the invention, pentaerythritol triallyl ether is adopted as a solvent during synthesis, the addition of an inert solvent in the existing process is optimized and removed, rectification recycling or environment-friendly treatment measures of the inert solvent are not needed, and high-pressure operation of taking water as the solvent is avoided, so that the reaction is beneficial to the generation of pentaerythritol triallyl ether.
BIO-NANO POWER CELLS AND THEIR USES
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Paragraph 0496; 0497; 0498; 0500; 0501; 0502, (2014/01/08)
The present invention concerns bio-nano power cells and methods of their manufacture and use. More particularly, the present invention relates to the preparation of bio-nano power cells that are biocompatible and capable of producing flash, intermittent, or continuous power by electrolyzing compounds in biological systems.