147867-65-0

Basic information

• Product Name: MPEG-2000-DSPE
• Synonyms: MPEG-2000-DSPE;alpha-[6-Hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-omega-methoxy-poly(oxy-1,2-ethanediyl);Poly(oxy-1,2-ethanediyl), α-[6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-ω-methoxy-
• CAS NO: 147867-65-0
• Molecular Formula: C45H87NNaO11P
• Molecular Weight: 872.135911
• Product Categories: PEG
• Mol File: 147867-65-0.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Sparingly), Methanol (Sparingly)
• CAS DataBase Reference: MPEG-2000-DSPE(CAS DataBase Reference)
• NIST Chemistry Reference: MPEG-2000-DSPE(147867-65-0)
• EPA Substance Registry System: MPEG-2000-DSPE(147867-65-0)

Safety Data

• Hazardous Substances Data: 147867-65-0(Hazardous Substances Data)

Usage

Description

MPEG-2000-DSPE, also known as Methoxy Polyethylene Glycol 2000 Distearoylphosphatidylethanolamine, is a type of amphiphilic molecule commonly used in the field of drug delivery. It possesses unique properties that allow it to form stable structures in aqueous environments, making it a promising candidate for various pharmaceutical applications.
Source:
MPEG-2000-DSPE is typically synthesized through the attachment of methoxy polyethylene glycol (MPEG) chains to distearoylphosphatidylethanolamine (DSPE) molecules.
Production Methods:
The production of MPEG-2000-DSPE involves the conjugation of MPEG chains to DSPE molecules, which can be achieved through various chemical reactions, such as the use of activated esters or click chemistry.

Uses

Used in Pharmaceutical Industry:
MPEG-2000-DSPE is used as a component in the formulation of liposomal drug delivery systems for improving the stability, biodistribution, and reducing the toxicity of antitubercular drugs targeting the lungs. Its amphiphilic nature allows for the formation of liposomes, which can encapsulate drugs and protect them from degradation, while also enhancing their targeting to specific tissues.
Used in Drug Delivery Systems:
MPEG-2000-DSPE is employed as a key ingredient in the development of novel drug delivery systems, particularly for cancer therapies. Its ability to form stable liposomal structures enables the encapsulation of various anticancer drugs, improving their delivery, bioavailability, and therapeutic outcomes. Additionally, MPEG-2000-DSPE can be used to modify the surface properties of nanoparticles, enhancing their circulation time and targeting capabilities in the body.
Used in Antitubercular Drug Development:
MPEG-2000-DSPE is utilized in the study of lung-specific liposomal antitubercular drugs, where it plays a crucial role in enhancing the stability and biodistribution of these drugs. By incorporating MPEG-2000-DSPE into the liposomal formulation, researchers can improve the drug's targeting to the lungs, reducing systemic toxicity and increasing the overall efficacy of the treatment.