148017-03-2

Basic information

• Product Name: (2R,4S)-4-nitrobenzyl 4-Mercapto-2-((sulfaMoylaMino)Methyl)pyrrolidine-1-carboxylate
• Synonyms: (2R,4S)-4-nitrobenzyl 4-Mercapto-2-((sulfaMoylaMino)Methyl)pyrrolidine-1-carboxylate;DoripeneM Side Chain 2;(2S,4S)-2-[[(Aminosulfonyl)amino]methyl]-4-mercapto-1-pyrrolidinecarboxylic acid (4-nitrophenyl)methyl ester;4-nitrobenzyl (2S,4S)-2-[(sulfamoylamino)methyl]-4-sulfanylpyrrolidine-1-carboxylate
• CAS NO: 148017-03-2
• Molecular Formula: C₁₃H₁₈N₄O₆S₂
• Molecular Weight: 390.43522
• EINECS: 1533716-785-6
• Mol File: 148017-03-2.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 624.895 °C at 760 mmHg
• Flash Point: 331.725 °C
• Appearance: /
• Density: 1.54 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.653
• PKA: 10.18±0.40(Predicted)
• CAS DataBase Reference: (2R,4S)-4-nitrobenzyl 4-Mercapto-2-((sulfaMoylaMino)Methyl)pyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4S)-4-nitrobenzyl 4-Mercapto-2-((sulfaMoylaMino)Methyl)pyrrolidine-1-carboxylate(148017-03-2)
• EPA Substance Registry System: (2R,4S)-4-nitrobenzyl 4-Mercapto-2-((sulfaMoylaMino)Methyl)pyrrolidine-1-carboxylate(148017-03-2)

Safety Data

• Hazardous Substances Data: 148017-03-2(Hazardous Substances Data)

Usage

General Description

"(2R,4S)-4-nitrobenzyl 4-Mercapto-2-((sulfaMoylaMino)Methyl)pyrrolidine-1-carboxylate" is a chemical compound with a complex structure. It contains a 4-nitrobenzyl group, a 4-mercapto-2-((sulfaMoylaMino)Methyl)pyrrolidine-1-carboxylate group, and a (2R,4S) configuration. The compound also contains a nitro group, which is known for its explosive and oxidizing properties, and a mercapto group, which has a strong odor and is commonly used in organic synthesis and as a reagent in chemical assays. The sulfaMoylaMino group is a derivative of the antibiotic sulfonamide and is often used in the treatment of bacterial infections. The overall structure and combination of functional groups suggest that this compound may have potential applications in the pharmaceutical industry, particularly in the development of antimicrobial agents.

InChI:InChI=1/C13H18N4O6S2/c14-25(21,22)15-6-11-5-12(24)7-16(11)13(18)23-8-9-1-3-10(4-2-9)17(19)20/h1-4,11-12,15,24H,5-8H2,(H2,14,21,22)/t11-,12-/m0/s1

Upstream product

• 101803-29-6 (2S,4R)-4-hydroxy-2-methoxycarbonyl-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 
• 138324-82-0 (2S,4R)-4-mesyloxy-1-(p-nitrobenzyloxycarbonyl)pyrrolidine-2-carboxylic acid methyl ester 
• 96034-97-8 (2S,4S)-4-acetylthio-2-methoxycarbonyl-1-p-nitrobenzyloxycarbonylpyrrolidine 
• 148017-06-5 (2S,4S)-1-p-nitrobenzyloxycarbonyl-2-aminomethyl-4-mercaptopyrrolidine 
• 148017-02-1 (2S,4S)-1-p-nitrobenzyloxycarbonyl-2-sulfamoylaminomethyl-4-tritylthiopyrrolidine 
• 491878-06-9 (2S,4S)-4-acetylthio-2-[[N-aminosulfonyl-N-(tert-butyloxycarbonyl)amino]methyl]pyrrolidine-1-carboxylic acid p-nitrobenzyl ester 

Downstream Products

• 148016-81-3 doripenem 
• 491878-07-0 (4R,5S,6S)-3-[[(3S,5S)-5-[[(aminosulfonyl)amino]methyl]-1-[[(4-nitrophenyl)methoxy]carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (4-nitrophenyl)methyl ester 

Relevant articles and documents

Preparation method for synthesizing doripenem side chain intermediate

The invention discloses a preparation method for synthesizing a doripenem side chain intermediate. The preparation method comprises the following steps: dissolving a compound IV serving as an initialraw material in an organic solvent I, and introducing am

Improved Large-scale One-pot Synthesis of Pure Doripenem Hydrate (S-4661)

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AN IMPROVED PROCESS FOR THE PREPARATION OF PYRROLIDINE THIOL DERIVATIVES USEFUL IN THE SYNTHESIS OF CARBAPENEM COMPOUNDS

The present invention relates to an improved process for the preparation of the compound of formula (III) which is used in the synthesis of carbapenem antibiotics. wherein R3 is hydrogen or an amine protecting group.