148762-54-3

Basic information

• Product Name: Pyrrolo[1,2-d][1,2,4]triazine-1,4-dione, hexahydro-3-(phenylmethyl)-, (S)-
• CAS NO: 148762-54-3
• Molecular Formula: C13H15N3O2
• Molecular Weight: 245.281
• Mol File: 148762-54-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Pyrrolo[1,2-d][1,2,4]triazine-1,4-dione, hexahydro-3-(phenylmethyl)-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolo[1,2-d][1,2,4]triazine-1,4-dione, hexahydro-3-(phenylmethyl)-, (S)-(148762-54-3)
• EPA Substance Registry System: Pyrrolo[1,2-d][1,2,4]triazine-1,4-dione, hexahydro-3-(phenylmethyl)-, (S)-(148762-54-3)

Safety Data

• Hazardous Substances Data: 148762-54-3(Hazardous Substances Data)

Upstream product

• 1108148-68-0 benzhydrylidene aza-glycinyl-proline methyl ester 
• 1234782-86-5 benzhydrylidene aza-phenylalaninyl-proline methyl ester 
• 24469-50-9 t-butyl 3-benzylidenecarbazate 
• 100-52-7 benzaldehyde 
• 53370-84-6 N'-benzylhydrazinecarboxylic acid tert-butyl ester 
• 148762-53-2 N-tert-Butoxycarbonylazaphenylalanyl-L-proline 
• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 
• 148762-52-1 2-(tert-butyl) 1-(4-nitrophenyl) 1-benzylhydrazine-1,2-dicarboxylate 

Downstream Products

• 148762-56-5 N-<(S)-2-Benzyloxypropionyl>-cyclo-(-azaphenylalanyl-L-prolyl-) 
• 195320-97-9 (R)-3-((S)-3-Benzyl-1,4-dioxo-hexahydro-pyrrolo[1,2-d][1,2,4]triazin-2-yl)-2-benzyloxy-2-methyl-3-oxo-propionic acid ethyl ester 
• 1027967-00-5 C₂₂H₂₇N₃O₈ 
• 195321-00-7 (2R,8aS,8bS)-4-Benzyl-8b-hydroxy-2-methyl-3,5-dioxo-octahydro-1-oxa-3a,4,5a-triaza-as-indacene-2-carbonyl azide 
• 195320-98-0 (2R,8aS,8bS)-4-Benzyl-8b-hydroxy-2-methyl-3,5-dioxo-octahydro-1-oxa-3a,4,5a-triaza-as-indacene-2-carboxylic acid ethyl ester 
• 195320-99-1 (2R,8aS,8bS)-4-Benzyl-8b-hydroxy-2-methyl-3,5-dioxo-octahydro-1-oxa-3a,4,5a-triaza-as-indacene-2-carboxylic acid 
• 195320-96-8 (S)-2-Benzyloxy-2-methyl-malonic acid (S)-3-benzyl-4-oxo-3,4,6,7,8,8a-hexahydro-pyrrolo[1,2-d][1,2,4]triazin-1-yl ester ethyl ester 

Relevant articles and documents

Combinatorial aid for underprivileged scaffolds: Solution and solid-phase strategies for a rapid and efficient access to novel aza-diketopiperazines (aza-DKP)

An efficient solution-phase synthesis of aza-diketopiperazines (aza-DKP, triazinediones) is reported. A structurally diverse collection of c-[aza-alkylGly-Pro] derivatives and yet unreported 2,4,5-trisubstituted-1,2,4- triazine-3,6-diones has been synthesized starting from Fmoc-l-Pro-OH and various Fmoc-l-amino acids. To extend the practical value of this class of dipeptidomimetics, a general solid-phase synthesis approach amenable to library production was developed on both Wang-PS and HMBA-PS resins. The final acidic treatment of the resins in TFA/water mixture at room temperature enabled the rapid and quantitative cyclization/release highly pure triazinediones. The conformational preferences and the spatial organization of the three substituents of a representative 2,4,5-trisubstituted-1,2,4-triazine-3,6-dione were investigated by X-ray diffraction and 1H NMR spectroscopy.

Approaches to Pseudopeptidic Ergopeptines. Synthesis and Molecular Structure of an α-Aza-phenylalanine-containing Oxa-cyclol

A synthesis of the tetrahedral adduct (oxa-cyclol) 6 structurally related to the peptide portion of ergotamine and possessing an α-aza-phenylalanine residue in place of the central phenylalanine is described.The reaction sequence comprises acylation of cy