14971-39-2Relevant articles and documents
Synthesis and biological evaluation of new antioxidant and antiproliferative chalcogenobiotin derivatives for bladder carcinoma treatment
Collares, Tiago,Dornelles, Luciano,Leitemberger, Andrielli,Nogara, Pablo A.,Piccoli, Bruna C.,Rodrigues, Oscar E. D.,Schachtschneider, Kyle M.,Seixas, Fabiana K.,Sonego, Mariana S.,da Silva, Fernanda D.,dos Santos, Alana C. F.,Garcia, Fábio D.,Oliveira, Cláudia S.,Rocha, Jo?o B. T.
, (2020/03/24)
Approximately 90% of bladder carcinomas are of the urothelial carcinoma type, which are characterized by high rates of recurrence and predisposition to progress to invasive tumors, representing one of the most costly neoplasms for health systems. Intraves
Evidence for a common selenolate intermediate in the glutathione peroxidase-like catalysis of α-(phenylselenenyl) ketones and diphenyl diselenide
Engman, Lars,Andersson, Claes,Morgenstern, Ralf,Cotgreave, Ian A.,Andersson, Carl-Magnus,Hallberg, Anders
, p. 2929 - 2938 (2007/10/02)
The glutathione peroxidase-like catalysis of α-(phenylselenenyl) ketones was investigated. Degradation studies demonstrated the rapid cleavage of the aliphatic carbon-selenium bond of α-(phenylselenenyl) ketones by glutathione at pH 6.9 in a methanolic phosphate buffer under argon. On treatment with excess glutathione under aerobic conditions, α-(phenylselenenyl) ketones, S- (phenylselenenyl)glutathione and diphenyl diselenide were all shown to give benzeneselenolate. This material was found to be oxidized by hydrogen peroxide considerably faster than α-(phenylselenenyl) ketones, S- (phenylselenenyl)glutathione or diphenyl diselenide. A catalytic mechanism involving benzeneselenolate, benzeneselenenic acid and S- (phenylselenenyl)glutathione as crucial intermediates was proposed to account for the glutathione peroxidase-like catalysis of α-(phenylselenenyl) ketones and diphenyl diselenide.