150806-61-4Relevant articles and documents
METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION
-
Paragraph 0558; 0560, (2021/11/20)
Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present disclosure can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.
1,2-NAPHTHOQUINONE DERIVATIVE AND METHOD FOR PREPARING SAME
-
Paragraph 0261; 0262, (2016/11/21)
Disclosed are a compound represented by Formula (1), or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, tautomer, enantiomer, or pharmaceutically acceptable diastereomer thereof, a method of preparing the same, and a pharmaceutical composition, which have effects for treatment or prevention of metabolic syndromes, comprising the same: wherein R1to R6, X1 to X4, and n are the same as defined in Claim 1.
Use of the composite material RuO2/BaTi4O9 as an environmentally benign solid catalyst for the oxidative cleavage of olefins
Okumoto, Hiroshi,Ohtsuka, Kazuhiro,Banjoya, Shinji
, p. 3201 - 3205 (2008/09/20)
Catalytic use of a composite material, RuO2/BaTi 4O9, in combination with NaIO4 in EtOAc-H 2O has been shown to efficiently cleave alkenes, affording ketones, aldehydes and/or carboxylic acids in high yields. Georg Thieme Verlag Stuttgart.
