1516886-27-3

Basic information

• Product Name: C₆₈H₉₁N₁₅O₁₈
• CAS NO: 1516886-27-3
• Molecular Weight: 1406.56
• Mol File: 1516886-27-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₆₈H₉₁N₁₅O₁₈(CAS DataBase Reference)
• NIST Chemistry Reference: C₆₈H₉₁N₁₅O₁₈(1516886-27-3)
• EPA Substance Registry System: C₆₈H₉₁N₁₅O₁₈(1516886-27-3)

Safety Data

• Hazardous Substances Data: 1516886-27-3(Hazardous Substances Data)

Upstream product

• 68858-20-8 Fmoc-Val-OH 
• 35661-60-0 Fmoc-Leu-OH 
• 35661-39-3 N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine 
• 1516886-34-2 (2S,7S,E)-8-tert-butoxycarbonyl-2-tert-butoxycarbonylamino-7-((9H-fluoren-9-yl)methoxycarbonylamino)hept-4-enoic acid 
• 112883-29-1 N-Fmoc-Tyr-OH 
• 35661-40-6 N-Fmoc L-Phe 
• 136083-57-3 N-α-9-fluorenylmethoxycarbonyl-aspartic acid 
• 116611-64-4 (9-fluorenylmethoxycarbonyl)-L-histidine 

Relevant articles and documents

Replacement of the disulfide bridge in a KLK3-stimulating peptide using orthogonally protected building blocks

Peptide B-2 , which is one of the most potent kallikrein-related peptidase 3 (KLK3)-stimulating compounds, consists of 12 amino acids and is cyclized by a disulfide bridge between the N- and C-terminal cysteines. Orthogonally protected building blocks were used in the peptide synthesis to introduce a disulfide bridge mimetic consisting of four carbon atoms. The resulting pseudopeptides with alkane and E-alkene linkers doubled the proteolytic activity of KLK3 at a concentration of 14 μM. They were almost as potent as the parent B-2 peptide, which gives a 3.6-fold increase in the proteolytic activity of KLK3 at the same concentration.