154307-84-3

Basic information

• Product Name: (2S,5S)-5-hydroxypiperidine-2-carboxylic acid hydrochloride
• Synonyms: (2S,5S)-5-hydroxypiperidine-2-carboxylic acid hydrochloride;EOS-62364;2-Piperidinecarboxylic acid, 5-hydroxy-, hydrochloride (1:1), (2S,5S)-;(2S,5S)-5-hydroxypiperidine-2-carboxylic acid hydrogen chloride
• CAS NO: 154307-84-3
• Molecular Formula: C6H12ClNO3
• Molecular Weight: 181.61738
• Mol File: 154307-84-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: (2S,5S)-5-hydroxypiperidine-2-carboxylic acid hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,5S)-5-hydroxypiperidine-2-carboxylic acid hydrochloride(154307-84-3)
• EPA Substance Registry System: (2S,5S)-5-hydroxypiperidine-2-carboxylic acid hydrochloride(154307-84-3)

Safety Data

• Hazardous Substances Data: 154307-84-3(Hazardous Substances Data)

Usage

General Description

(2S,5S)-5-hydroxypiperidine-2-carboxylic acid hydrochloride is a chemical compound that is a derivative of piperidine. It is a hydrochloride salt and contains a 5-hydroxy group, as well as a carboxylic acid group on the piperidine ring. (2S,5S)-5-hydroxypiperidine-2-carboxylic acid hydrochloride is commonly used in the synthesis of pharmaceuticals and other organic compounds due to its unique structural characteristics. It is important in the field of medicinal chemistry and drug development, as it can serve as a building block for the creation of new drugs and therapeutic agents. Additionally, the hydrochloride salt form of this compound makes it more water-soluble, which can be beneficial for certain applications in the pharmaceutical industry.

Upstream product

• 1253856-42-6 (2S,5S)-di-tert-butyl 5-hydroxypiperidine-1,2-dicarboxylate 
• 133008-09-0 (R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propanal 
• 1383814-52-5 (2S,5S)-tert-butyl 5-hydroxypiperidine-2-carboxylate 
• 169825-97-2 N-benzyloxycarbonyl-(2S,5S)-5-hydroxypipecolic acid tert-butyl ester 
• 147489-30-3 (2S)-5-oxopiperidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester 
• 81470-51-1 tert-butyl N-benzyloxycarbonyl-L-pyroglutamate 
• 32159-21-0 Cbz-L-pGlu-OH 
• 154049-29-3 methyl (2S,5S)-5-t-butyldimethylsilyloxy-N-methoxycarbonyl-piperidine-2-carboxylate 
• 154049-28-2 (2S,5S)-5-t-butyldimethylsilyloxy-N-methoxycarbonyl-2-hydroxymethyl-piperidine 
• 154049-27-1 (2S,5S)-5-t-butyldimethylsilyloxy-N-methoxycarbonyl-2-hydroxymethyl-piperidine 
• 154049-26-0 (5S)-5-t-butyldimethylsilyloxy-N-methoxycarbonyl-2-methylene-piperidine 
• 138565-91-0 (5S)-methyl 5-(tert-butyldimethylsilanyloxy)-2-oxopiperidine-1-carboxylate 
• 87179-81-5 (-)-(5S)-5-(tert-butyldimethylsilanyloxy)piperidin-2-one 
• 24211-54-9 (S)-5-hydroxypiperidin-2-one 

Downstream Products

• 1174020-25-7 (2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylic acid 
• 1416134-73-0 (2S,5R)-5-((benzyloxy)amino)piperidine-2-carboxylate methyl ester 
• 1383814-58-1 (2S,5R)-6-benzyloxy-7-oxo-1,6-diazabicyclo[3.2.1]octan-2-carboxylic acid methyl ester 
• 1426572-71-5 (2S,5R)-N’-acetyl-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carbohydrazide 
• 1452467-32-1 (2S,5R)-6-(benzyloxy)-7-oxo-N’-propanoyl-1,6-diazabicyclo[3.2.1]octane-2-carbohydrazide 
• 1452466-57-7 (2S,5R)-6-(benzyloxy)-N-methoxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 
• 1452466-19-1 {2-[({[(2S,5R)-6-benzyloxy-7-oxo-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl}amino)oxy]ethyl}carbamic acid tert-butyl ester 
• 1452458-86-4 RG₆₀₈₀ 
• 1426573-07-0 (2S,5R)-1-[(1,1-dimethylethyl)carbonyl]-5-[(benzyloxy)amino]piperidine-2-carboxylic acid 
• 1487347-86-3 (2S,5S)-N-tert-butoxycarbonyl-5-hydroxy-2-carboxylic acid piperidine 

Relevant articles and documents

Stereodivergent synthesis of 5-aminopipecolic acids and application in the preparation of a cyclic RGD peptidomimetic as a nanomolar αvβ3 integrin ligand

A stereodivergent strategy was devised to obtain enantiopure cis and trans 5-aminopipecolic acids (5-APAs) in suitably protected forms to be employed in peptide synthesis as conformationally constrained α- and δ-amino acids. The cis isomer was used as a δ-amino acid to construct a cyclic RGD-containing peptidomimetic, the ability of which to compete with biotinylated vitronectin for binding with the isolated αVβ3 integrin was measured (IC50 = 4.2 ± 0.9 nM). A complete 1H NMR and computational conformational analysis was performed to elucidate the reasons for the high affinity of this cyclic peptidomimetic in comparison with cilengitide.

Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions

The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.