1622-32-8 Usage
Description
2-Chloroethanesulfonyl chloride is a clear, slightly yellow to brown liquid with a density of 1.56 g/cm3 and a flash point that exceeds 230°F. It is a chemical compound known for its versatile applications in various industries, particularly in the synthesis of different organic compounds.
Uses
Used in Pharmaceutical Industry:
2-Chloroethanesulfonyl chloride is used as a reagent for the one-pot sulfonylation/intramolecular thia-Michael protocol, which is crucial for the synthesis of 1,5,2-dithiazepine 1,1-dioxides. These compounds have potential applications in the development of new pharmaceuticals due to their unique chemical structures and properties.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-Chloroethanesulfonyl chloride is utilized as a key intermediate in the synthesis of vinyl sulfonamides with a furan, carbocyclic, semi-cyclic, or acyclic 1,3-diene moiety. These synthesized compounds can be further used in various applications, such as the development of new materials, pharmaceuticals, and agrochemicals.
Overall, 2-Chloroethanesulfonyl chloride is a valuable chemical compound with a wide range of applications in different industries, particularly in the synthesis of complex organic molecules and pharmaceuticals. Its unique chemical properties and reactivity make it an essential tool for researchers and chemists in their quest to create novel and innovative products.
Air & Water Reactions
Reacts with water to produce corrosive and toxic gaseous hydrogen chloride.
Reactivity Profile
2-CHLOROETHANESULFONYL CHLORIDE is incompatible with strong oxidizing agents, alcohols, amines, alkali. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Check Digit Verification of cas no
The CAS Registry Mumber 1622-32-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,2 and 2 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1622-32:
(6*1)+(5*6)+(4*2)+(3*2)+(2*3)+(1*2)=58
58 % 10 = 8
So 1622-32-8 is a valid CAS Registry Number.
InChI:InChI=1/C2H4Cl2O2S/c3-1-2-7(4,5)6/h1-2H2
1622-32-8Relevant articles and documents
A sulfonamidoquinoline-derived Zn2+ fluorescent sensor with 1:1 Zn2+ binding stoichiometry
Zhang, Changli,Zhang, Yuming,Chen, Yuncong,Xie, Zhijun,Liu, Zhipeng,Dong, Xindian,He, Weijiang,Shen, Chen,Guo, Zijian
, p. 304 - 307 (2011)
The integration of bis(pyridin-2-ylmethyl)amine (BPA) with 8-sulfonamidoquinoline (SQ) resulted in a new fluorescent Zn2+ sensor of 1:1 binding stoichiometry. The synergic Zn2+ coordination of BPA and SQ motifs provides the sensor the advantage over TSQ and its analogues in discriminating mobile Zn2+ from the bound Zn2+ of unoccupied coordination sites in living systems. Its pH-independent Zn 2+-enhanced emission in physiological condition and cell permeability make it an effective intracellular Zn2+ imaging agent. This sensor profits also from its confirmed Golgi-preferential affinity, and its pH-independent Zn2+ response in physiological pH range provides it the advantages over other xanthenone-based sensors.
Iwakura,Nakabayashi
, p. 142,146, 149 (1963)
Iridinesulfonamide compound and use method thereof
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Paragraph 0101-0103, (2018/03/29)
An iridinesulfonamide compound having isocitrate dehydrogenase 1 (IDH1) inhibitory activity, pharmaceutically-acceptable salts, solvates or hydrates thereof, a pharmaceutical composition, as well as use of the compound or the pharmaceutically-acceptable salts, solvates or hydrates thereof, and the pharmaceutical composition thereof in treating IDH1 mutation-induced cancers.
PROCESS FOR PREPARATION OF NARATRIPTAN HYDROCHLORIDE
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Page/Page column 28-29, (2009/10/22)
The present invention relates to an improved process for the preparation of N-methyl-3- (1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide hydrochloride of formula (I) having less than 0.15 % area by HPLC of 3-(1-methyl-4-piperidinyl)-1H-indole-5- ethanesulfonamide (1A) and intermediates thereof.