1622453-05-7

Basic information

• Product Name: C₁₅H₁₅F₃N₂
• CAS NO: 1622453-05-7
• Molecular Weight: 280.293
• Mol File: 1622453-05-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₅F₃N₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₅F₃N₂(1622453-05-7)
• EPA Substance Registry System: C₁₅H₁₅F₃N₂(1622453-05-7)

Safety Data

• Hazardous Substances Data: 1622453-05-7(Hazardous Substances Data)

Upstream product

• 865869-28-9 (4,4-dimethylcyclohex-1-en-1-yl)boronic acid 
• 386704-06-9 2-chloro-6-(trifluoromethyl)nicotinonitrile 
• 116548-04-0 2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile 

Downstream Products

• 1622453-18-2 C₁₅H₂₁F₃N₂ 
• 1622453-27-3 C₁₅H₁₉F₃N₂ 
• 1622452-90-7 C₂₅H₃₁F₄N₃O₃S 
• 1622452-98-5 C₂₅H₂₉F₄N₃O₃S 
• 1622453-29-5 C₂₅H₃₁F₄N₃O₃S 
• 1622453-32-0 C₂₅H₂₉F₄N₃O₃S 

Relevant articles and documents

2-Alkyl/alkenyl substituted pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as highly potent TRPV1 antagonists

A series of 2-alkyl/alkenyl pyridine C-region derivatives of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides were investigated as hTRPV1 antagonists. Multiple compounds showed excellent and stereospecific TRPV1 antagonism with better potency than previous lead 2. Among them, compound 15f demonstrated a strong analgesic profile in a rat neuropathic pain model and blocked capsaicin-induced hypothermia in a dose-dependent manner. Docking analysis of (S)-15f with our hTRPV1 homology model provided insight into its specific binding mode.