1637-45-2 Usage
Description
2,2-dimethyl-1,2,3,4-tetrahydroisoquinolinium is a quaternary ammonium compound with a molecular formula of C13H19N and a molecular weight of 189.29 g/mol. It features a tetrahydroisoquinoline core structure and is characterized by its colorless to pale yellow liquid appearance with a pungent odor. 2,2-dimethyl-1,2,3,4-tetrahydroisoquinolinium is soluble in water and most organic solvents, and is commonly utilized in organic synthesis and as a precursor for the preparation of pharmaceuticals and other organic compounds. Additionally, it has garnered research interest due to its potential pharmaceutical and biological activity, particularly as a cholinesterase inhibitor and in the treatment of neurodegenerative diseases.
Uses
Used in Organic Synthesis:
2,2-dimethyl-1,2,3,4-tetrahydroisoquinolinium serves as a valuable intermediate in organic synthesis, facilitating the creation of a variety of complex organic compounds. Its unique tetrahydroisoquinoline core structure allows for versatile chemical reactions, making it a useful building block in the synthesis of pharmaceuticals and other organic molecules.
Used as a Precursor in Pharmaceutical Preparation:
2,2-dimethyl-1,2,3,4-tetrahydroisoquinolinium is also used as a precursor in the preparation of various pharmaceuticals. Its ability to be modified and incorporated into different molecular structures makes it an important component in the development of new drugs and therapeutic agents.
Used in the Development of Cholinesterase Inhibitors:
2,2-dimethyl-1,2,3,4-tetrahydroisoquinolinium has shown potential as a cholinesterase inhibitor, which is a significant application in the realm of pharmaceuticals. Cholinesterase inhibitors are crucial for the treatment of neurodegenerative diseases, such as Alzheimer's disease, by increasing the levels of acetylcholine in the brain, thereby improving cognitive function.
Used in the Treatment of Neurodegenerative Diseases:
With its potential as a cholinesterase inhibitor, 2,2-dimethyl-1,2,3,4-tetrahydroisoquinolinium is also being explored for its use in the treatment of neurodegenerative diseases. Research is focused on understanding its efficacy in managing the progression of these diseases and improving the quality of life for affected individuals.
Check Digit Verification of cas no
The CAS Registry Mumber 1637-45-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,3 and 7 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1637-45:
(6*1)+(5*6)+(4*3)+(3*7)+(2*4)+(1*5)=82
82 % 10 = 2
So 1637-45-2 is a valid CAS Registry Number.
1637-45-2Relevant articles and documents
Insight into the Alkaline Stability of N-Heterocyclic Ammonium Groups for Anion-Exchange Polyelectrolytes
Chen, Nanjun,Fan, Jiantao,Hu, Chuan,Jin, Yiqi,Lee, Young Moo,Li, Hui,Liu, Haijun,Wu, Bo,Xu, Shaoyi
supporting information, p. 19272 - 19280 (2021/07/25)
The alkaline stability of N-heterocyclic ammonium (NHA) groups is a critical topic in anion-exchange membranes (AEMs) and AEM fuel cells (AEMFCs). Here, we report a systematic study on the alkaline stability of 24 representative NHA groups at different hydration numbers (λ) at 80 °C. The results elucidate that γ-substituted NHAs containing electron-donating groups display superior alkaline stability, while electron-withdrawing substituents are detrimental to durable NHAs. Density-functional-theory calculations and experimental results suggest that nucleophilic substitution is the dominant degradation pathway in NHAs, while Hofmann elimination is the primary degradation pathway for NHA-based AEMs. Different degradation pathways determine the alkaline stability of NHAs or NHA-based AEMs. AEMFC durability (from 1 A cm?2 to 3 A cm?2) suggests that NHA-based AEMs are mainly subjected to Hofmann elimination under 1 A cm?2 current density for 1000 h, providing insights into the relationship between current density, λ value, and durability of NHA-based AEMs.
GROUP 8 TRANSITION METAL CATALYSTS AND METHOD FOR MAKING SAME AND PROCESS FOR USE OF SAME IN OLEFIN DISPROPORTIONATION REACTIONS
-
Page/Page column 34-35; 38, (2017/12/09)
These catalyst compounds are represented by the formula (I and VI): wherein M is a Group 8 metal; X is an anionic ligand; L is a neutral two-electron donor ligand; A is a monotopic or ditopic chelating ligand. The present invention also relates to an easy applicable catalyst synthesis and the application in different olefin metathesis processes, e.g. Reaction Injection Molding (RIM), rotational molding, vacuum infusion, vacuum forming, process for conversion of fatty acids and fatty acid esters or mixtures thereof, in -olefins, dicarboxylic acids or dicarboxylic esters, etc.
Rearrangements of 1,6,7-Trisubstituted 2-Methyl-1,2,3,4-tetrahydroisoquinolinium 2-Methylides
Sato, Yoshiro,Shirai, Naohiro,Machida, Yoshio,Ito, Emiko,Yasui, Takayo,et al.
, p. 6711 - 6716 (2007/10/02)
Chemical behavior of 1,6,7-trisubstituted 2-methy-1,2,3,4-tetrahydroisoquinolinium 2-methylides 4 was investigated in fluoride-ion induced desilation reaction of 1,6,7-trisubstituted 2-methyl-2-(trimethylsilyl)methyl-1,2,3,4-tetrahydroisoquinolinium iodid