1643-60-3 Usage
Description
(2-Fluoro-6-nitrophenyl)methanol is a chemical compound with the molecular formula C7H6FNO3. It is a fluorinated nitrophenol derivative that is commonly used as an intermediate in organic synthesis. (2-Fluoro-6-nitrophenyl)methanol is characterized by the presence of a fluorine atom and a nitro group attached to a phenyl ring, with a hydroxymethyl group as the side chain. Its unique structure and functional groups make it an important building block in the synthesis of various pharmaceuticals and agrochemicals.
Uses
Used in Pharmaceutical Industry:
(2-Fluoro-6-nitrophenyl)methanol is used as a key intermediate in the synthesis of various types of medicines. Its fluorinated and nitro functional groups can be further modified or reacted with other molecules to produce a wide range of pharmaceutical compounds with different therapeutic properties. The incorporation of fluorine and nitro groups can enhance the bioactivity, selectivity, and pharmacokinetic properties of the resulting drugs.
Used in Agricultural Industry:
In the agricultural sector, (2-Fluoro-6-nitrophenyl)methanol serves as a precursor for the development of agrochemicals, such as pesticides and herbicides. Its unique chemical structure allows for the creation of compounds with improved efficacy, selectivity, and environmental compatibility. The use of this compound in agrochemicals can contribute to more effective and sustainable crop protection strategies.
Used in Research and Development Laboratories:
(2-Fluoro-6-nitrophenyl)methanol is also utilized in research and development laboratories for its versatile properties and potential applications in drug discovery and material science. Its reactivity and functional groups make it a valuable tool for exploring new chemical reactions, synthesis pathways, and the development of novel compounds with specific properties. Researchers can leverage the unique characteristics of this compound to advance their understanding of chemical processes and create innovative materials and therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 1643-60-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,4 and 3 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1643-60:
(6*1)+(5*6)+(4*4)+(3*3)+(2*6)+(1*0)=73
73 % 10 = 3
So 1643-60-3 is a valid CAS Registry Number.
1643-60-3Relevant articles and documents
6-Fluorophenylbenzohydrazides inhibit Mycobacterium tuberculosis growth through alteration of tryptophan biosynthesis
Arora, Kriti,Biava, Mariangela,Boshoff, Helena I.,Consalvi, Sara,De Logu, Alessandro,Ioerger, Thomas R.,Poce, Giovanna,Rubin, Eric J.,Venditti, Giulia,Zhu, Junhao
, (2021/09/16)
A major constraint in reducing tuberculosis epidemic is the emergence of strains resistant to one or more of clinically approved antibiotics, which emphasizes the need of novel drugs with novel targets. Genetic knockout strains of Mycobacterium tuberculosis (Mtb) have established that tryptophan (Trp) biosynthesis is essential for the bacterium to survive in vivo and cause disease in animal models. An anthranilate-like compound, 6-FABA, was previously shown to synergize with the host immune response to Mtb infection in vivo. Herein, we present a class of anthranilate-like compounds endowed with good antimycobacterial activity and low cytotoxicity. We show how replacing the carboxylic moiety with a hydrazide led to a significant improvement in both activity and cytotoxicity relative to the parent compound 6-FABA. Several new benzohydrazides (compounds 20–31, 33, 34, 36, 38 and 39) showed good activities against Mtb (0.625 ≤ MIC≤6.25 μM) and demonstrated no detectable cytotoxicity against Vero cell assay (CC50 ≥ 1360 μM). The target preliminary studies confirmed the hypothesis that this new class of compounds inhibits Trp biosynthesis. Taken together, these findings indicate that fluorophenylbenzohydrazides represent good candidates to be assessed for drug discovery.
