1644-76-4 Usage
Purine Family
Belongs to the purine family of compounds.
Structural Composition
Purine core structure
Chlorine atom at position 6
Methyl group at position 9
Trifluoromethyl group at position 2
Potential Applications
Pharmaceutical industry applications
Drug development targeting purine receptors
Unique Properties
Valuable building block for synthesizing novel purine-based molecules
Diverse biological activities due to unique structure
Fluorinated moiety may enhance bioavailability and metabolic stability
Advantages for Drug Development
Attractive candidate due to enhanced bioavailability and metabolic stability
Potential for developing drugs with improved efficacy and pharmacokinetic properties.
Check Digit Verification of cas no
The CAS Registry Mumber 1644-76-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,4 and 4 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1644-76:
(6*1)+(5*6)+(4*4)+(3*4)+(2*7)+(1*6)=84
84 % 10 = 4
So 1644-76-4 is a valid CAS Registry Number.
InChI:InChI=1/C7H4ClF3N4/c1-15-2-12-3-4(8)13-6(7(9,10)11)14-5(3)15/h2H,1H3
1644-76-4Relevant articles and documents
Synthetic studies directed towards agelasine analogs - Synthesis, tautomerism, and alkylation of 2-substituted N-methoxy-9-methyl-9H-purin-6- amines
Roggen, Heidi,Gundersen, Lise-Lotte
experimental part, p. 5099 - 5106 (2009/06/06)
N-Methoxy-9-methyl-9H-purin-6-amines, carrying various substituents in the 2 positions, were synthesized by the N-methylation of known 6-chloropurines, followed by a displacement of the chlorine. Great variations in the amino/imino tautomer ratio among the compounds studied were observed. The tautomers were identified by NMR methods. Treatment of N-methoxy-9-methyl-9H-purin-6-amines carrying alkyl, alkoxy, or amino substituents in the 2 position with benzyl bromide resulted in a mixture of N-7- and N6-benzylated compounds with the former as the major products. N-Methoxy-9-methyl-9H-purin-6-amines with strongly electronegative substituents at C-2 hardly reacted at all under the same set of reaction conditions. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
FLUORINE-CONTAINING POTENTIAL ANTICANCER AGENTS. II. SYNTHESES OF SOME
NAGANO,INOUE,SAGGIOMO,NODIFF
, p. 215 - 220 (2007/10/08)
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