1648-39-1

Basic information

• Product Name: Phosphinothioic fluoride, diphenyl-
• CAS NO: 1648-39-1
• Molecular Formula: C12H10FPS
• Molecular Weight: 236.25
• Mol File: 1648-39-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Phosphinothioic fluoride, diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphinothioic fluoride, diphenyl-(1648-39-1)
• EPA Substance Registry System: Phosphinothioic fluoride, diphenyl-(1648-39-1)

Safety Data

• Hazardous Substances Data: 1648-39-1(Hazardous Substances Data)

Usage

General Description

Phosphinothioic fluoride, diphenyl- is a chemical compound with the formula (C6H5)2P(S)F. It is a colorless, foul-smelling liquid that is highly toxic and can cause severe burns on contact with skin. Phosphinothioic fluoride, diphenyl- is often used as a reagent in organic synthesis, particularly in the production of phosphine oxides and phosphine sulfides. It is also a potent insecticide and acaricide, commonly used to control pests in agricultural and industrial settings. Due to its extreme toxicity, strict safety measures must be followed when handling and disposing of phosphinothioic fluoride, diphenyl-.

Upstream product

• 1015-37-8 diphenylthiophosphinoyl chloride 
• 80358-37-8 N,S-Bis(diphenylthiophosphinyl)-cysteamin 

Relevant articles and documents

New General Synthesis of Organophosphorus P-F Compounds via Reaction of Azolides of Phosphorus Acids with Acyl Fluorides: Novel Route to 2-Deoxynucleosidyl Phosphorofluoridates and Phosphorodifluoridates

Tetra- and tri-coordinate P-N-imidazole derivatives and their structural analogous react smoothly with acyl fluorides to give the corresponding P-F compounds an almost quantitative yield.This method has been successfully applied to produce 2-deoxynucleosidyl phosphorofluoridates and phosphorodifluoridates.

PHOSPHORORGANISCHE VERBINDUNGEN 97. Die Diphenylphosphinyl- und die Diphenylthiophosphinylgruppe als selektive Schutzgruppe fuer die Mercaptofunktion. Nucleophile Abloesung der Thioloestergruppe aus Thiophosphin-, Thiophosphon- und Thiophosphorsaeure-S-estern durch nicht solvatisierte...

Diphenylphosphinic acid cyanide and diphenylthiophosphonic acid cyanide react selectively with the mercaptogroup even in presence of primary aminogroups.The thioloesterbond in thiophosphinic, thiophosphonic and thiophosphoric acid S-esters is cleaved under mild conditions by unsolvated fluoride ions F*3H2O (R = C4H9) and CsF> in methylene chloride, chloroform or THF. (C6H5)2P(O)CN and (C6H5)2P(S)CN are therefore protecting group reagents for mercaptans.Diphenylphosphinic acid chloride and diphenylthiophosphinic acid chloride are N-selective in competing reactions using butylamine/butylmercaptan.In contrast to the corresponding S-selective cyanides no selectivity is observed using cysteamine and cysteinmethylester.