16507-00-9

Basic information

• Product Name: 4-NITRO-4-METHYLVALERONITRILE
• Synonyms: TIMTEC-BB SBB000088;4-NITRO-4-METHYLVALERONITRILE;4-METHYL-4-NITROVALERONITRILE
• CAS NO: 16507-00-9
• Molecular Formula: C₆H₁₀N₂O₂
• Molecular Weight: 142.16
• Mol File: 16507-00-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 105-107 °C(Press: 1 Torr)
• Appearance: /
• Density: 1.095 g/cm3(Temp: 25 °C)
• CAS DataBase Reference: 4-NITRO-4-METHYLVALERONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-NITRO-4-METHYLVALERONITRILE(16507-00-9)
• EPA Substance Registry System: 4-NITRO-4-METHYLVALERONITRILE(16507-00-9)

Safety Data

• Hazardous Substances Data: 16507-00-9(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 21, p. 107, 1956 DOI: 10.1021/jo01107a023

Upstream product

• 79-46-9 2-nitropropane 
• 107-13-1 acrylonitrile 
• 552-89-6 2-nitro-benzaldehyde 
• 112-02-7 cetyltrimethylammonium chloride 

Downstream Products

• 5165-28-6 5,5-dimethyl-2-pyrrolidone 
• 32827-16-0 4-methyl-4-nitropentanoic acid 
• 34211-69-3 2-amino-5,5-dimethylpyrroline 1-oxide 
• 3123-97-5 dihydro-5,5-dimethyl-2(3H)-furanone 
• 105090-82-2 (4-Amino-4-methyl-pentyl)-carbamic acid tert-butyl ester 
• 542-54-1 isocapronitrile 

Relevant articles and documents

Intermolecular domino Michael/aldol reactions of α,β-unsaturated esters, aromatic aldehydes, and various nucleophiles promoted with a catalytic amount of a guanidine base in DMSO

In DMSO, a catalytic amount of Barton's base (2-t-butyl-1,1,3,3-tetramethylguanidine, BTMG) effectively catalyzed intermolecular three-component reactions of α,β-unsaturated esters, aldehydes, and carbon-, sulfur-, or nitrogen-pronucleophiles to give three-component addition products with the formation of two new σ-bonds: pronucleophiles and aldehydes reacted with α,β-unsaturated esters at their β-positions and α-positions, respectively. Mechanism studies suggested that these reactions proceeded by the first intermolecular Michael addition of anionic nucleophiles that were formed from pronucleophiles with a catalytic amount of BTMG, followed by intermolecular aldol reactions of transient ester enolates even in the presence of more than stoichiometric amounts of acidic pronucleophiles. High nucleophilicity over Br?nsted basicity of transient enolates in polar solvents was observed for transient ester enolates rather than ketone enolates.

2-Substituted nitrones and isomeric hydroxylamines - obtained via aluminium amalgam reduction of nitro nitriles and ketones-a new access to convenient intermediates for nitroso carbonyl compounds preparation

Substituted five-membered cyclic nitrones (pyrroline N-oxides) have been obtained in good to high yields from tertiary γ-nitro ketones and nitriles employing aluminium amalgam as a reducing agent in moist diethyl ether or THF. Attempts to obtain cyclic amino nitrones from α- or β-nitro nitriles failed and only the corresponding hydroxylamines have been isolated. Both nitrones and hydroxylamines have been used for synthesis of tertiary C-nitroso nitriles or ketones.

Method for producing lysine derivative

The present invention provides a method for industrially producing an optically active lysine derivative useful as a pharmaceutical intermediate. More particularly, the present invention provides a production method including protecting an amino group or an amino group and carboxyl group of optically active 2-amino-6-methyl-6-nitroheptanoic acid with a protecting group, reducing a nitro group to synthesize a 6,6-dimethyl lysine derivative and reacting the 6,6-dimethyl lysine derivative with an acetic acid derivative.