1655-57-8

Basic information

• Product Name: N-(2,4-DINITROPHENYL)-L-LEUCINE
• Synonyms: N-(2,4-DINITROPHENYL)-L-LEUCINE;N-DNP-L-LEUCINE;DNP-L-LEUCINE;DNP-L-Leucine 2,4-Dinitrophenyl-L-leucine;N-2-4-dnp-L-leucine;dnp-leu-oh;TRANSFERRIN, FROM MURINE;(S)-2-[(2,4-Dinitrophenyl)amino]-4-methylpentanoic acid
• CAS NO: 1655-57-8
• Molecular Formula: C₁₂H₁₅N₃O₆
• Molecular Weight: 297.26
• Product Categories: Amino Acids;Amino Acids (N-Protected);Biochemistry;DNP-Amino Acids
• Mol File: 1655-57-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 98 °C
• Boiling Point: 509.7°Cat760mmHg
• Flash Point: 262.1°C
• Appearance: /
• Density: 1.412g/cm³
• Solubility: almost transparency in Methanol
• PKA: 3?+-.0.22(Predicted)
• CAS DataBase Reference: N-(2,4-DINITROPHENYL)-L-LEUCINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,4-DINITROPHENYL)-L-LEUCINE(1655-57-8)
• EPA Substance Registry System: N-(2,4-DINITROPHENYL)-L-LEUCINE(1655-57-8)

Safety Data

• RIDADR: 1325
• HazardClass: 4.1
• PackingGroup: II
• Hazardous Substances Data: 1655-57-8(Hazardous Substances Data)

Usage

General Description

N-(2,4-Dinitrophenyl)-L-leucine, also known as DNPL-leucine, is a chemical compound that belongs to the category of dinitrophenyl derivatives. It is a derivative of the amino acid leucine and the dinitrophenyl group is often used as a chromophore in colorimetric assays for the detection of amino acids. DNPL-leucine is commonly used in biochemistry and molecular biology research to study protein structure and function, as well as in enzyme kinetics studies. It can also be used as a chiral derivatizing reagent for the analysis of amino acids by high-performance liquid chromatography. Overall, DNPL-leucine is an important chemical tool that is widely used in biochemical research and analysis.

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Relevant articles and documents

ANTIMICROBIAL PEPTIDES AND METHODS OF USE

Cyclic depsipeptide-class molecules, referred to herein as persephacins (including analogs thereof), having similarities to aureobasidin A, are described. The persephacins have antimicrobial activity, such as antifungal activity against a diverse range of clinically -relevant fungal pathogens, antiprotozoan parasite activity, and antibacterial activity, and can be used for example in treatments of difficult-to-treat ocular fungal infections at lower concentrations than natamycin. The active compounds may be combined with a secondary compound in a composition.

Simple and efficient preparation of (R)- and (S)-enantiomers of α-carbon deuterium-labelled α-amino acids

A procedure for the synthesis of (R)- and (S)-enantiomers of α-carbon deuterium-labelled α-amino acids, exemplified for (R)- and (S)-[2-2H1]-Leu is described. Starting from the respective (S)- or (R)-enantiomer or from the racemic mixture of an α-amino acid the selective proton exchange at the α-carbon is carried out by racemization via a Schiff base in monodeuterated acetic acid as solvent which serves as deuterium source. After N-protection the racemic mixture is liquid chromatographically separated into the individual (R)- and (S)-enantiomers on preparative scale employing a chiral anion exchanger based on carbamoylated quinine as chiral selector. After deprotection the enantiomerically pure products can be obtained in good yields.