1656285-34-5

Basic information

• Product Name: C₂₁H₂₇NO₄
• Synonyms: C₂₁H₂₇NO₄
• CAS NO: 1656285-34-5
• Molecular Weight: 357.45
• Mol File: 1656285-34-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₇NO₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₇NO₄(1656285-34-5)
• EPA Substance Registry System: C₂₁H₂₇NO₄(1656285-34-5)

Safety Data

• Hazardous Substances Data: 1656285-34-5(Hazardous Substances Data)

Upstream product

• 530-59-6 trans-3,5-dimethoxy-4-hydroxycinnamic acid 
• 665-66-7 amantadine hydrochloride 

Relevant articles and documents

Synthesis and biological activity of hydroxycinnamoylcontaining antiviral drugs

Seven N-hydroxycinnamoyl amides were synthesized by 1-[3-(dimethylamino) propyl]-3-ethylcarbodiimide/1-hydroxybenzotriazole (EDC/HOBt) coupling of the corresponding substituted cinnamic acids (p-coumaric-, ferulic-, sinapic- and caffeic acids) with influenza antivirals (amantadine, rimantadine and oseltamivir). The DPPH (1,1-diphenyl-2-picrylhydrazyl) scavenging abilities and the inhibitory effect on mushroom tyrosinase activity (using L-tyrosine as the substrate) were investigated in vitro. Amongst the synthesized compounds, N-[(E)-3-(3,4-dihydroxyphenyl)-2-propenoyl]oseltamivir (1) and N-[(E)-3-(3,4-dihydroxyphenyl)-2-propenoyl]rimantadine (4), containing a catechol moiety, exhibited the most potent DPPH radical-scavenging activity. Amide (1) also displayed tyrosinase inhibitory effect toward L-tyrosine as the substrate (=50 %). The synthesized compounds were also investigated for their in vitro inhibitory activity against the replication of influenza virus A (H3N2).