1657-53-0Relevant articles and documents
Heck reactions with very low ligandless catalyst loads accelerated by microwaves or simultaneous microwaves/ultrasound irradiation
Palmisano, Giovanni,Bonrath, Werner,Boffa, Luisa,Garella, Davide,Barge, Alessandro,Cravotto, Giancarlo
, p. 2338 - 2344 (2007)
Heck couplings were carried out ligandless in air with very low catalyst loads under microwave or simultaneous microwave/ultrasound irradiation. Using ligand-free palladium(II) acetate [Pd(OAc)2] in the range of 0.01-0.1 mol% or palladium-oncarbon (Pd/C) 10% in the range of 1.0-2.0 mol%, most aryl iodides and bromides gave high yields under conventional heating (120 °C) in 18 h. MicroWave irradiation alone or, better still, combined with high-intensity ultrasound, strongly promotes the reaction, generally decreasing reaction times to 1 h. Electron-poor aryl chlorides such as 4-chloroacetophenone and l-chloro-4-nitrobenzene reacted with styrene to afford high product yields in the presence of 0.25 mol% Pd(OAc)2 or 2.0-3.0 mol% Pd/C. In several cases the addition of a co-catalyst, either rhodium tris(triphenylphosphine) chloride, 0.005 mol%, or a copper(I) salt (iodide or bromide), 2.0-4.0 mol %, proved very advantageous. 4-Bromo- and 4-chloroacetophenone afforded up to 15 % of oxidation products, namely the corresponding 4-halobenzoic acid and 4-styrylbenzoic acid, a drawback that was avoid ed by working under a nitrogen atmosphere.
Palladium Nanoparticle-Catalyzed Stereoretentive Cross-Coupling of Alkenyl Sulfides with Grignard Reagents
Jeanne-Julien, Louis,Astier, Eloi,Lai-Kuen, René,Genta-Jouve, Grégory,Roulland, Emmanuel
, p. 1430 - 1434 (2018)
Reaction conditions allowing a stereoretentive cross-coupling of alkenyl sulfides with Grignard reagents using ligand-free Pd catalysis are discussed here. The presence of an adequately positioned OH function is a key feature that allows a Mg-promoted Lewis acid activation of the mercaptide leaving group. This easy to implement procedure actually relies on an in situ generation of stable Pd nanoparticles by simply mixing Pd2(dba)3, the Grignard reagent, and the vinyl sulfide cross-coupling partner in THF. The efficiency of this procedure has been demonstrated in a natural product total synthesis context.
New Pd-NHC-complexes for the Mizoroki-Heck reaction
Taige, Maria A.,Zeller, Alexander,Ahrens, Sebastian,Goutal, Sigrid,Herdtweck, Eberhardt,Strassner, Thomas
, p. 1519 - 1529 (2007)
The synthesis and structural characterization of novel chelating N-aryl substituted palladium(II)-biscarbene-complexes is reported: 1,1′-bis(4-bromophenyl)-3,3′-methylene-diimidazoline-2,2′-diylidene-palladium(II)-dibromide, 1,1′-bis(4-methoxyphenyl)-3,3′-methylene-diimidazoline-2,2′-diylidene-palladium(II)-dibromide and 1,1′-bis(4-n-butoxyphenyl)-3,3′-methylenediimidazoline-2,2′-diylidene-palladium(II)-dibromide have been synthesized in good yields. The catalytic activity of these 1,1′-aryl-3,3′-methylenediimidazoline-2,2′-diylidene-palladium(II)-dihalogenide complexes was tested for the Mizoroki-Heck reaction in comparison to 1,1′-(bis)methyl-3,3′-methylenediimidazoline-2,2′-diylidene-palladium(II)-dihalogenide complexes and to 1,1′-bis(phenyl)-3,3′-methylene-diimidazoline-2,2′-diylidene-palladium(II)-dibromide. The activity of the aryl substituted catalysts is significantly higher compared to the methyl substituted NHC complexes. They also allow the coupling of arylchlorides with olefins.
Phosphine-Functionalized Chitosan Microparticles as Support Materials for Palladium Nanoparticles in Heck Reactions
Biajoli, André F. P.,Fajardo, André R.,Lemos, Thalia S. A.,de Souza, Jaqueline F.
, (2022/01/11)
Herein, we investigated the activation and stabilization of Pd nanoparticles using microparticles of chitosan-functionalized with phosphine moieties. The catalytic activity of the prepared material was assessed in a series of Heck reactions, which demonst
A Solid-Phase Assisted Flow Approach to In Situ Wittig-Type Olefination Coupling
Aldrich-Wright, Janice R.,Dankers, Christian,Gordon, Christopher P.,Polyzos, Anastasios,Tadros, Joseph
supporting information, p. 4184 - 4194 (2021/08/24)
Described herein is the development of a continuous flow, solid-phase triphenylphosphine (PS-PPh3) assisted protocol to facilitate the in situ coupling of reciprocal pairs of halogen and carbonyl functionalised molecular pairs by a Wittig olefination within 15 mins. The protocol entails injecting a single solution (1 : 1 CHCl3 : EtOH) containing the halogenated and carbonyl-based substrates into a continuously flowing stream of CHCl3 : EtOH (1 : 1), passed through a fixed bed of K2CO3 and PS-PPh3. With advancement to the previous PS-PPh3 coupling procedures, the method employs a traditional polystyrene-based immobilisation matrix, the substrate scope of the protocol extended to substituted ketones, secondary alkyl chlorides, and an unprotected maleimide scaffold.