16618-67-0

Basic information

• Product Name: 3-BROMO-5-NITROANISOLE
• Synonyms: 3-BROMO-5-NITROANISOLE;3-BROMO-5-NITROANISOL;3-BROMO-5-NITROANISOL, 97.5+%;1-Bromo-3-methoxy-5-nitrobenzene;Benzene, 1-bromo-3-methoxy-5-nitro-;1-Bromo-3-methoxy-5-nitrobenzene, 3-Bromo-5-nitrophenyl methyl ether;1-BroMo-5-Nitroanizole
• CAS NO: 16618-67-0
• Molecular Formula: C₇H₆BrNO₃
• Molecular Weight: 232.03144
• Product Categories: Naphthyridine,Quinoline
• Mol File: 16618-67-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 86.0 to 90.0 °C
• Boiling Point: 295.303 °C at 760 mmHg
• Flash Point: 132.395 °C
• Appearance: /
• Density: 1.64 g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.581
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 3-BROMO-5-NITROANISOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-5-NITROANISOLE(16618-67-0)
• EPA Substance Registry System: 3-BROMO-5-NITROANISOLE(16618-67-0)

Safety Data

• Hazardous Substances Data: 16618-67-0(Hazardous Substances Data)

Usage

Chemical Properties

brown solid

InChI:InChI=1/C7H6BrNO3/c1-12-7-3-5(8)2-6(4-7)9(10)11/h2-4H,1H3

Upstream product

• 88149-47-7 2,4-dibromo-6-methoxyaniline 
• 18242-39-2 3,5-dinitrobromobenzene 
• 124-41-4 sodium methylate 
• 16618-66-9 2-bromo-6-methoxy-4-nitro-phenylamine 
• 33844-21-2 2-nitro-4-methoxybenzoic acid 
• 67-56-1 methanol 
• 5327-44-6 3,5-dinitroanisole 
• 99-65-0 meta-dinitrobenzene 
• 7697-37-2 nitric acid 
• 586-10-7 3-methoxy-5-nitroaniline 

Downstream Products

• 16618-68-1 3-bromo-5-methoxyaminobenzene 
• 116632-23-6 3-bromo-5-nitro-phenol 
• 33224-19-0 3-methoxy-5-nitrobenzonitrile 
• 1192471-83-2 tert-Butyl {3-[(E)-2-(3-methoxy-5-nitrophenyl)vinyl]phenyl}carbamate 
• 1401462-53-0 (S)-4-(7-(3-methoxy-5-(2-methylpyrrolidin-1-yl)phenylamino)thiazolo[5,4-d]pyrimidin-5-yl)benzoic acid 
• 1401462-51-8 (S)-5-chloro-N-(3-methoxy-5-(2-methylpyrrolidin-1-yl)phenyl)thiazolo[5,4-d]pyrimidin-7-amine 
• 1401462-50-7 (S)-3-methoxy-5-(2-methylpyrrolidin-1-yl)benzenamine 
• 1254058-71-3 1–(3-methoxy-5-nitrophenyl)-4-methylpiperazine 
• 915412-18-9 1-bromo-3-iodo-5-methoxybenzene 
• 927407-98-5 5-(7-chloro-quinolin-4-ylamino)-4'-trifluoromethyl-biphenyl-3-ol 
• 927408-08-0 4'-chloro-5-(7-chloro-1-oxy-quinolin-4-ylamino)-biphenyl-3-ol 

Relevant articles and documents

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Synthesis of 1,5-bifunctional organolithium reagents by a double directed ortho-metalation: Direct transformation of esters into 1,8-dimethoxy-acridinium salts

The impact of electronic and steric factors on the selectivity of the electrophilic aromatic substitution amounts to several limitations in accessing specific substitution patterns. Nucleophiles generated by directed metalation represent an effective alte

PROTEIN KINASE INHIBITORS

A compound of formula (I), wherein R3, R4, G, B, M, and Z are as defined in the claims, and pharmaceutically acceptable salts thereof are disclosed. The compounds of formula (I) possess utility as FGFR inhibitors and are useful in the treatment of a condition, where FGFR kinase inhibition is desired, such as cancer.