16639-46-6

Basic information

• Product Name: 7-Allyloxy-5-hydroxy-2-methylchromone
• Synonyms: 7-Allyloxy-5-hydroxy-2-methyl-4H-1-benzopyran-4-one;7-Allyloxy-5-hydroxy-2-methylchromone
• CAS NO: 16639-46-6
• Molecular Formula: C₁₃H₁₂O₄
• Molecular Weight: 232.23
• Mol File: 16639-46-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 109-110 °C
• Boiling Point: 417.6±45.0 °C(Predicted)
• Appearance: /
• Density: 1.251±0.06 g/cm3(Predicted)
• PKA: 6.48±0.40(Predicted)
• CAS DataBase Reference: 7-Allyloxy-5-hydroxy-2-methylchromone(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Allyloxy-5-hydroxy-2-methylchromone(16639-46-6)
• EPA Substance Registry System: 7-Allyloxy-5-hydroxy-2-methylchromone(16639-46-6)

Safety Data

• Hazardous Substances Data: 16639-46-6(Hazardous Substances Data)

Upstream product

• 1013-69-0 eugenin 
• 106-95-6 allyl bromide 
• 144152-27-2 1-[2,4,6-tris(acetyloxy)phenyl]ethanone 
• 56147-47-8 2-methyl-4-oxo-4H-chromene-5,7-diyl diacetate 
• 480-66-0 2,4,6-trihydroxyacetophenone 

Downstream Products

• 1203490-49-6 7-{2''-[(tert-butyldiphenylsiloxy)methyl]allyloxy}-8-allyl-5-hydroxy-2-methyl-4H-chromen-4-one 
• 1203490-48-5 7-{2''-[(tert-butyldiphenylsiloxy)methyl]allyloxy}-6-allyl-5-hydroxy-2-methyl-4H-chromen-4-one 
• 17981-91-8 Ptaeroxylinol 

Relevant articles and documents

Synthesis and Antifungal Activity of Chromones and Benzoxepines from the Leaves of Ptaeroxylon obliquum

This study reports the first total synthesis of the bioactive oxepinochromones 12-O-acetyleranthin (8) (angular isomer) and 12-O-acetylptaeroxylinol (9) (linear isomer). The antifungal activity of these compounds and their derivatives was determined against Candida albicans and Cryptococcus neoformans. Most compounds had good selectivity between the two fungi and showed moderate to good activity. 12-O-Acetyleranthin (8) had the highest activity against C. albicans, with an MIC value of 9.9 μM, while 12-O-acetylptaeroxylinol (9), the compound present in Ptaeroxylon obliquum, had the highest activity against C. neoformans, with an MIC value of 4.9 μM.