168897-19-6

Basic information

• Product Name: Pyrrolidine, 1-[2-(4-nitrophenyl)ethyl]-
• CAS NO: 168897-19-6
• Molecular Formula: C12H16N2O2
• Molecular Weight: 220.271
• Mol File: 168897-19-6.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Pyrrolidine, 1-[2-(4-nitrophenyl)ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolidine, 1-[2-(4-nitrophenyl)ethyl]-(168897-19-6)
• EPA Substance Registry System: Pyrrolidine, 1-[2-(4-nitrophenyl)ethyl]-(168897-19-6)

Safety Data

• Hazardous Substances Data: 168897-19-6(Hazardous Substances Data)

Upstream product

• 123-75-1 pyrrolidine 
• 100-13-0 4-nitrostyrene 
• 5339-26-4 (4-nitrophenyl)ethyl bromide 
• 20020-28-4 <(p-Nitrophenyl)ethyl>-β-sulfonic ester 
• 20264-96-4 2-(4-nitrophenyl)ethyl iodide 
• 51738-10-4 2,2-dibromo-1-(4-nitrophenyl)ethene 
• 555-16-8 4-nitrobenzaldehdye 
• 168897-62-9 2-(4-nitrophenyl)-1-(pyrrolidin-1-yl)ethan-1-one 
• 103-63-9 1-phenyl-2-bromoethane 

Downstream Products

• 1567327-13-2 2-(4-(2-(pyrrolidin-1-yl)ethyl)phenyl)benzo[d][1,2]selenazol-3(2H)-one 
• 1567327-19-8 5,6-dimethoxy-2-(4-(2-(pyrrolidin-1-yl)ethyl)phenyl)benzo[d][1,2]selenazol-3(2H)-one 
• 168897-20-9 4-(2-pyrrolidin-1-yl-ethyl)phenylamine 

Relevant articles and documents

Synthesis and biological evaluation of a new series of ebselen derivatives as glutathione peroxidase (GPx) mimics and cholinesterase inhibitors against Alzheimer's disease

A series of ebselen derivatives were designed, synthesised and evaluated as inhibitors of cholinesterases (ChEs) and glutathione peroxidase (GPx) mimics. Most of the compounds were found to be potent against AChEs and BuChE, compounds 5e and 5i, proved to be the most potent against AChE with IC50 values of 0.76 and 0.46 μM, respectively. Among these hybrids, most of the compounds were found to be good GPx mimics compare with ebselen. The selected compounds 5e and 5i were also used to determine the catalytic parameters and in vitro hydrogen peroxide scavenging activity. The results indicate that compounds 5e and 5i may be excellent multifunctional agents for the treatment of AD.

Synthesis and biological evaluation of new 4β-anilino-4′-O- demethyl-4-desoxypodophyllotoxin derivatives as potential antitumor agents

A series of new 4β-anilino-4′-O-demethyl-4-desoxypodophyllotoxin derivatives were prepared and evaluated for their cytotoxicities against four human cancer cell lines including KB, KB/VCR, A549 and 95D. Most compounds showed better growth-inhibition activities against tested cell lines than that of etoposide (VP-16). Preliminary structure-activity relationships (SARs) were concluded and it indicated that the side chains substituted at 4β position of podophyllotoxin significantly influenced the cytotoxic activity, especially for the drug resistance profile. In vivo studies of compound 26c on highly metastatic human lung cancer xenograft in nude mice showed that it can significantly inhibit tumor growth with administrating by oral route.

In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: Trends across multiple chemical series

Structure-activity relationships (SAR) were analyzed within a library of diverse yet simple compounds prepared as histamine H3 antagonists. The libraries were constructed with a variety of low molecular weight pyrrolidines, selected from (R)-2-methylpyrrolidine, (S)-2-methylpyrrolidine, and pyrrolidine.