1699-58-7

Basic information

• Product Name: 3,4-bis(benzyloxy)benzyl alcohol
• Synonyms: 3,4-bis(benzyloxy)benzyl alcohol;3,4-Bis(benzyloxy)benzenemethanol;3,4-Bis(phenylmethoxy)benzenemethanol
• CAS NO: 1699-58-7
• Molecular Formula: C₂₁H₂₀O₃
• Molecular Weight: 320.3817
• EINECS: 216-926-5
• Mol File: 1699-58-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 494.4°Cat760mmHg
• Flash Point: 252.8°C
• Appearance: /
• Density: 1.175g/cm³
• Vapor Pressure: 1.36E-10mmHg at 25°C
• Refractive Index: 1.614
• CAS DataBase Reference: 3,4-bis(benzyloxy)benzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-bis(benzyloxy)benzyl alcohol(1699-58-7)
• EPA Substance Registry System: 3,4-bis(benzyloxy)benzyl alcohol(1699-58-7)

Safety Data

• Hazardous Substances Data: 1699-58-7(Hazardous Substances Data)

Usage

General Description

3,4-bis(benzyloxy)benzyl alcohol is a chemical compound with the molecular formula C21H22O3. It is a white crystalline solid that is commonly used in the synthesis of organic compounds and pharmaceuticals. 3,4-bis(benzyloxy)benzyl alcohol is known for its ability to act as a versatile building block for the construction of complex molecular structures due to its unique chemical reactivity. It is also used as a reagent in various chemical reactions, such as in the formation of carbon-carbon bonds and the synthesis of biologically active molecules. Additionally, 3,4-bis(benzyloxy)benzyl alcohol has potential applications in the development of new drugs and materials due to its diverse chemical properties and potential for modification and functionalization.

InChI:InChI=1/C21H20O3/c22-14-19-11-12-20(23-15-17-7-3-1-4-8-17)21(13-19)24-16-18-9-5-2-6-10-18/h1-13,22H,14-16H2

Upstream product

• 5447-02-9 3,4-dibenzyloxybenzaldehyde 
• 54544-05-7 3,4-bis-benzyloxybenzoic acid methyl ester 
• 99-50-3 3,4-Dihydroxybenzoic acid 
• 2150-43-8 3,4-dihydroxybenzoic acid methyl ester 
• 100-39-0 benzyl bromide 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 100-44-7 benzyl chloride 
• 882427-72-7 3,4-(bisbenzyloxy)benzoic acid benzyl ester 

Downstream Products

• 150258-69-8 1,2-bis(benzyloxy)-4-(bromomethyl)benzene 
• 1699-60-1 (3,4-bis-benzyloxyphenyl)acetonitrile 
• 78178-56-0 3,4-dibenzyloxy-phenylacetyl chloride 
• 1250409-46-1 1,2-bis(benzyloxy)-5-bromomethyl-4-iodobenzene 

Relevant articles and documents

Designing new analogs for streamlining the structure of cytotoxic lamellarin natural products

Despite the therapeutic potential of marine-derived lamellarin natural products, their preclinical development has been hampered by their lipophilic nature, causing very poor aqueous solubility. In order to develop more drug-like analogs, their structure was streamlined in this study from both the cytotoxic activity and lipophilicity standpoints. First, a modified total synthetic route was successfully devised to construct a library of 59 systematically designed lamellarin analogs, which were then subjected to cytotoxicity and log P determinations. Along with the 25 first-generation lamellarins previously synthesized in our laboratory, the structure-activity and structure-lipophilicity relationships were extensively evaluated. Our results clearly indicated the additional structural requirements around the lamellarin skeleton which, when combined with those reported previously, can provide invaluable guidance for further modifications to increase the aqueous solubility of these compounds.

CAFFEINATED COMPOUNDS AND COMPOSITIONS FOR TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES

Compounds and their pharmaceutically acceptable salts for treatment of Beta-amyloid diseases, such as observed in Alzheimer's disease and synucleinopathies, such as Parkinson's disease

NO-CARRIER-ADDED NUCLEOPHILIC [F-18] FLUORINATION OF AROMATIC COMPOUNDS

Phenyliodonium ylide derivatives substituted with electron donating as well as electron withdrawing groups on the aromatic ring are shown for use as precursors in aromatic nucleophilic substitution reactions. The iodonium ylide group is substituted by nucleophiles such as halide ions to provide the corresponding haloaryl derivatives. No- carrier-added [F-18]fluoride ion exclusively substitutes the iodonium ylide moiety in these derivatives and provides high specific activity F- 18 labeled fluoro derivatives. Protected L-dopa-6-iodonium ylide derivative have been synthesized as a precursors for the preparation of no-carrier-added 6-[F- 18]fluoro-L-dopa. The iodonium ylide group in this L-dopa.derivative is nucleophilically substituted by no-carrier-added [F-18]fluoride ion to provide a [F-18]fluoro intermediates which upon acid hydrolysis yielded 6-[F- 18]fluoro-L-dopa.