1701-57-1

Basic information

• Product Name: 2,3,4,5-Tetrahydro-1H-benzo[b]azepine
• Synonyms: 2,3,4,5-TETRAHYDRO-1H-BENZO[B]AZEPINE;2,3,4,5-TETRAHYDRO-1H-BENZO[B]AZEPINE HYDROCHLORIDE;2,3,4,5-Tetrahydro-1H-benzo[b]azepin
• CAS NO: 1701-57-1
• Molecular Formula: C₁₀H₁₃N
• Molecular Weight: 147.22
• Product Categories: pharmacetical
• Mol File: 1701-57-1.mol
• Article Data: 48

Chemical Properties

• Melting Point: 32 °C
• Boiling Point: 268.9 °C at 760 mmHg
• Flash Point: 122.7 °C
• Appearance: /
• Density: 0.981 g/cm³
• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: 1.531
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 5.22±0.20(Predicted)
• CAS DataBase Reference: 2,3,4,5-Tetrahydro-1H-benzo[b]azepine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4,5-Tetrahydro-1H-benzo[b]azepine(1701-57-1)
• EPA Substance Registry System: 2,3,4,5-Tetrahydro-1H-benzo[b]azepine(1701-57-1)

Safety Data

• Hazardous Substances Data: 1701-57-1(Hazardous Substances Data)

Usage

Uses

2,3,4,5-Tetrahydro-1H-1-benzazepine is a reactant in the synthesis of adamantane derivatives as cannabinoid receptor 2 agonists.

InChI:InChI=1/C10H13N/c1-2-7-10-9(5-1)6-3-4-8-11-10/h1-2,5,7,11H,3-4,6,8H2

Upstream product

• 4424-80-0 2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one 
• 7732-18-5 water 
• 119-64-2 tetralin 
• 17718-14-8 Methyl 1,2-Dihydroquinoline-1-carboxylate 
• 91-22-5 quinoline 
• 209967-15-7 4-(2-aminophenyl)but-3-yn-1-ol 
• 864512-14-1 2-iodophenyl 4-chlorobenzenesulfonate 
• 19886-89-6 1-Acetyl-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 832684-26-1 (+/-)-1-azido-1,2,3,4-tetrahydronaphthalene 
• 529-33-9 1,2,3,4-Tetrahydro-1-naphthol 
• 847173-91-5 1,2,3,4-tetrahydronaphthalen-1-yl methanesulfonate 
• 201230-82-2 carbon monoxide 
• 32704-22-6 2-allyl-phenylamine 
• 58490-87-2 1,2,3,4-tetrahydro-N-hydroxyl-1-naphthaleneamine 

Downstream Products

• 535960-89-5 N-[6-(2-methyl-4-chlorophenoxy)pyridin-3-yl]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxamide 
• 535960-85-1 N-[6-(4-methoxyphenoxy)pyridin-3-yl]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxamide 
• 535960-86-2 N-[6-(4-chlorophenoxy)pyridin-3-yl]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxamide 
• 535960-87-3 N-[6-(2-fluorophenoxy)pyridin-3-yl]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxamide 
• 535960-88-4 N-[6-(2-isopropoxyphenoxy)pyridin-3-yl]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxamide 
• 535960-90-8 N-[6-(3-methyl-4-chlorophenoxy)pyridin-3-yl]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxamide 
• 535960-91-9 N-[6-(2,4-dichlorophenoxy)pyridin-3-yl]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxamide 
• 535960-92-0 N-[6-(4-chloro-3,5-dimethylphenoxy)pyridin-3-yl]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxamide 
• 4425-15-4 4,5,6,7-tetrahydro-azepino[3,2,1-hi]indole-1,2-dione 
• 34583-83-0 7-nitro-2,3,4,5-tetrahydro-1H-benzo[d]azepiney 
• 65797-77-5 α,α-bis(trifluoromethyl)-2,3,4,5-tetrahydro-1H-1-benzazepine-7-methanol 
• 879999-66-3 1-benzenesulfonyl-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 434934-78-8 1-[2-nitrophenylsulfonyl]-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 65596-57-8 1-formyl-2,3,4,5-tetrahydro-1H-1-benzazepine 

Relevant articles and documents

Regioselectivity in Forming Dipole-Stabilized Anions. Sites of Metalation of Indolines, Tetrahydroquinolines, and Benzazepines Activated by N-Formimidoyl or N-Boc Groups

Metalation of the title compounds indicated that the formamidine-equipped indolines or 1,2,3,4-tetrahydroquinolines give rise solely to C-2 alkylation products (5,6) whereas the corresponding N-t-Boc systems give only ortho aryl alkylation (7,8).

Dehydrogenative and Redox-Neutral N-Heterocyclization of Aminoalcohols Catalyzed by Manganese Pincer Complexes

A new manganese catalyzed heterocyclization of aminoalcohols has been accomplished. A wide range of heterocycles were synthesized, including 1,2,3,4-tetrahydroquinolines, dihydroquinolinones, and 2,3,4,5-tetrahydro-1H-benzo[b]azepines. The reaction is performed under mild reaction conditions using air and moisture stable manganese catalysts. The desired heterocycles were obtained in good to excellent yields.

Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model

Histone deacetylase 6 (HDAC6) is a promising therapeutic target for the treatment of neurodegenerative disorders. SW-100 (1a), a phenylhydroxamate-based HDAC6 inhibitor (HDAC6i) bearing a tetrahydroquinoline (THQ) capping group, is a highly potent and sel

Mild, Metal-Free Oxidative Ring-Expansion Approach for the Synthesis of Benzo[ b]azepines

Benzo[b]azepines are important structural motifs for the pharmaceutical industry. However, their syntheses are usually lengthy, involving several steps, transition-metal catalysts, and/or harsh conditions. A novel, general, mild, and metal-free oxidative ring expansion tandem reaction of hydroquinolines with TMSCHN2 as a versatile soft nucleophile to gain access to these valuable compounds in a simple and straightforward manner is presented.