1701-71-9

Basic information

• Product Name: 4-Butyrylpyridine
• Synonyms: 1-(4-Pyridinyl)-1-butanone;1-(4-Pyridinyl)butane-1-one;4-Butyrylpyridine;4-Butanoylpyridine;1-(Pyridin-4-yl)butan-1-one
• CAS NO: 1701-71-9
• Molecular Formula: C9H11 N O
• Molecular Weight: 149.21
• Mol File: 1701-71-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 270.27°C (rough estimate)
• Flash Point: 109.4°C
• Appearance: /
• Density: 1.0753 (rough estimate)
• Vapor Pressure: 0.0265mmHg at 25°C
• Refractive Index: 1.5760 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform
• PKA: 3.21±0.10(Predicted)
• CAS DataBase Reference: 4-Butyrylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Butyrylpyridine(1701-71-9)
• EPA Substance Registry System: 4-Butyrylpyridine(1701-71-9)

Safety Data

• Hazardous Substances Data: 1701-71-9(Hazardous Substances Data)

Usage

Description

4-Butyrylpyridine, also known as 1-(Pyridin-4-yl)butan-1-one, is an organic compound that serves as an intermediate in the synthesis of various pharmaceutical compounds. It is characterized by the presence of a pyridine ring and a butyryl group, which contribute to its chemical properties and reactivity.

Uses

Used in Pharmaceutical Industry:
4-Butyrylpyridine is used as an intermediate in the synthesis of SB 202474 (S154615), a compound structurally similar to p38 MAP kinase inhibitors such as SB 202190 (S154495) and SB 203580 (S154600). These inhibitors play a crucial role in the regulation of cellular processes, including inflammation, cell growth, and apoptosis, making them valuable targets for drug development.
4-Butyrylpyridine is used as a research tool for p38 inhibition studies, aiding in the understanding of the role of p38 MAP kinases in various diseases and the development of potential therapeutic agents targeting this pathway.

Safety Profile

A poison by intraperitoneal route. A flammable liquid. When heated to decomposition it emits toxic vapors of NOx.

InChI:InChI=1/C9H11NO/c1-2-3-9(11)8-4-6-10-7-5-8/h4-7H,2-3H2,1H3

Upstream product

• 100-48-1 pyridine-4-carbonitrile 
• 927-77-5 n-propylmagnesium bromide 
• 872-85-5 pyridine-4-carbaldehyde 
• 72824-04-5 2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 18085-89-7 1-(pyridin-4-yl)butan-1-ol 
• 106-94-5 propyl bromide 
• 74-96-4 ethyl bromide 
• 108-03-2 1-Nitropropane 

Downstream Products

• 317861-31-7 4-aminomethyl-N-[1-(4-butyl-pyridin-2-yl)-2-cyclohexyl-ethyl]-benzamide 
• 317861-29-3 5-Amino-pentanoic acid [(S)-1-(4-butyl-pyridin-2-yl)-2-cyclohexyl-ethyl]-amide 

Relevant articles and documents

4-Pyridyl carbonyl compounds as thrips lures: Effectiveness for western flower thrips in Y-tube bioassays

In a search for chemical lures to manage the cosmopolitan crop pest western flower thrips (WFT), Frankliniella occidentalis, a Y-tube olfactometer was used to screen 20 compounds, including 18 4-pyridyl compounds. Comparison of Y-tube results for New Zealand flower thrips (NZFT), Thrips obscuratus, with field trapping data for ethyl nicotinate and ethyl isonicotinate, suggested that the minimum attractive dose (MAD) of an odor compound, where significantly (p -3 μL) and ethyl nicotinate (10-2 μL): methyl isonicotinate (10-6 μL), ethyl-2-chloropyridine-4-carboxylate (10-6 μL), ethyl isonicotinate (10-4 μL) and methyl 4-pyridyl ketone (10 -5 μL). The suitability of MAD for selecting compounds for further evaluation of practical lure efficacy is discussed. Comparisons of activities within homologous series of esters and ketones showed that attractant activity decreased with chain length. 4-Formyl pyridine was an attractant at a dose of 10-5 μL, but was repellent at higher doses (10-2- 10° μL).

Comparative inhibition of tetrameric carbonyl reductase activity in pig heart cytosol by alkyl 4-pyridyl ketones

Context and objective: The present study is to elucidate the comparative inhibition of tetrameric carbonyl reductase (TCBR) activity by alkyl 4-pyridyl ketones, and to characterize its substrate-binding domain. Materials and methods: The inhibitory effect

INSECT BEHAVIOUR MODIFYING COMPOUNDS

The invention provides methods for controlling thrips populations using thrips-repelling and/or thrips-attracting agents. The agents are derivatives of pyridine. The invention also provides methods of preventing or minimising damage to plants by use of the same.