1701-72-0

Basic information

• Product Name: 1-(3-PYRIDINYL)-1-PENTANONE
• Synonyms: 1-(3-PYRIDINYL)-1-PENTANONE;1-(3-pyridinyl)-1-pentanone(SALTDATA: FREE);3-Valerylpyridine
• CAS NO: 1701-72-0
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.22
• Mol File: 1701-72-0.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 270.005°C at 760 mmHg
• Flash Point: 124.289°C
• Appearance: /
• Density: 0.997g/cm³
• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: 1.501
• Storage Temp.: 2-8°C
• PKA: 3.24±0.10(Predicted)
• CAS DataBase Reference: 1-(3-PYRIDINYL)-1-PENTANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-PYRIDINYL)-1-PENTANONE(1701-72-0)
• EPA Substance Registry System: 1-(3-PYRIDINYL)-1-PENTANONE(1701-72-0)

Safety Data

• Hazardous Substances Data: 1701-72-0(Hazardous Substances Data)

Usage

General Description

1-(3-Pyridinyl)-1-pentanone, also known as 3-acetylpyridine, is a chemical compound with the molecular formula C10H11NO. It is a pale yellow liquid that is primarily used as a flavoring agent in the food and beverage industry. It has a sweet, caramel-like odor and is commonly found in products such as desserts, candy, and baked goods. In addition to its flavoring properties, 1-(3-pyridinyl)-1-pentanone is also used in the production of pharmaceuticals and as a solvent in various industrial processes. It is considered to be relatively safe for use in food and consumer products when used in accordance with regulatory guidelines.

InChI:InChI=1/C10H13NO/c1-2-3-6-10(12)9-5-4-7-11-8-9/h4-5,7-8H,2-3,6H2,1H3

Upstream product

• 500-22-1 3-pyridinecarboxaldehyde 
• 62485-87-4 butyl-iodo-manganese 
• 64531-95-9 nicotinoyl ethylcarbonate 
• 18085-86-4 1-(pyridin-3-yl)pentan-1-ol 
• 93-60-7 methyl 3-pyridinecarboxylate 
• 109-72-8 n-butyllithium 
• 100-54-9 pyridine-3-carbonitrile 
• 79-22-1 methyl chloroformate 
• 693-03-8 n-butyl magnesium bromide 
• 626-55-1 3-Bromopyridine 
• 110-59-8 pentanonitrile 
• 60573-68-4 3-pyridyllithium 
• 124-38-9 carbon dioxide 
• 1889-20-9 n-butylmagnesium iodide 

Downstream Products

• 129813-36-1 1-(2,5-Dimethoxy-3,4,6-trimethyl-phenyl)-1-pyridin-3-yl-pentan-1-ol 
• 614-18-6 3-pyridinecarboxylic acid ethyl ester 
• 360-34-9 1,1,1-trifluoro-2-hexanone 
• 1802-20-6 3-pentyl-pyridine 
• 129813-41-8 3-[1-(2,5-Dimethoxy-3,4,6-trimethyl-phenyl)-pentyl]-pyridine 
• 129813-39-4 3-[(Z)-1-(2,5-Dimethoxy-3,4,6-trimethyl-phenyl)-pent-1-enyl]-pyridine 
• 117574-35-3 2-[1-(pyridin-3-yl)pentyl]-3,5,6-trimethyl-1,4-benzoquinone 

Relevant articles and documents

HMPA-catalyzed transfer hydrogenation of 3-carbonyl pyridines and other N-heteroarenes with trichlorosilane

A method for the HMPA (hexamethylphosphoric triamide)-catalyzed metal-freetransfer hydrogenation of pyridines has been developed. The functional group tolerance of the existing reaction conditions provides easy access to various piperidines with ester or ketone groups at the C-3 site. The suitability of this method for the reduction of other N-heteroarenes has also been demonstrated. Thirty-three examples of different substrates have been reduced to designed products with 45–96% yields.

Eintopfsynthese von Ketonen und Aldehyden aus Kohlendioxid und Organolithiumverbindungen

-

Dual Inhibitors of Thromboxane A2 Synthase and 5-Lipoxygenase with Scavenging Activity of Active Oxygen Species. Synthesis of a Novel Series of (3-Pyridylmethyl)benzoquinone Derivatives

A novel series of (3-pyridylmethyl)benzoquinone derivatives was molecular designed and synthesized for the dual purpose of inhibiting thromboxane A2 and leukotriene biosynthesis enzymes and scavenging active oxygen species (AOS).They were evaluated for inhibition of TXA2 synthase, inhibition of 5-lipoxygenase, and for their scavenging activity of AOS using the thiobarbituric acid method. 2,3,5-Trimethyl-6-(3-pyridylmethyl)-1,4-benzoquinone (24, CV-6504) was the most promising derivative since it showed efficient AOS scavenging activity (inhibition of lipid peroxidation in rat brain homogenates: IC50 = 1.8 10-6 M) as well as potent, specific, and well-balanced inhibitory effects on both enzymes (inhibitory effect on TXA2 synthase in human blood, IC50 = 3.3 10-7 M; inhibitory effect on 5-lipoxygenase in human blood, IC50 = 3.6 10-7 M).In adriamycin-induced proteinuria in a rat model, compound 24 at 10 mg/kg per day (po) suppressed proteinuria by more than 50percent.The proteinuria, however, could not be reduced by single administration of an inhibitor specific for thromboxane A2 synthase or for 5-lipoxygenase .The proteinuria was also not reduced by administration of an AOS scavenger, 2-O-octadecylascorbic acid (4, CV-3611).Triple function compounds such as compound 24 that specifically inhibit both enzymes as well as scavenge AOS possess a variety of pharmacologically beneficial effects.