170151-24-3 Usage
Description
Nepicastat hydrochloride is a potent and selective dopamine β-hydroxylase (DBH) inhibitor, characterized by its high specificity for DBH over a range of other enzymes and neurotransmitter receptors. Nepicastat hydrochloride is known for its ability to dose-dependently reduce norepinephrine content while increasing dopamine content in various tissues, such as the mesenteric artery, left ventricle, and cerebral cortex. Its pharmacological profile includes attenuating blood pressure and heart rate increases induced by preganglionic sympathetic nerve stimulation, as well as modulating behavioral responses related to cocaine-seeking in animal models.
Uses
Used in Cardiovascular Treatment:
Nepicastat hydrochloride is utilized as a therapeutic agent in cardiovascular treatment, specifically addressing conditions where ventricular deficiencies result in heart failure. Its mechanism of action involves the inhibition of dopamine β-hydroxylase, which leads to reduced norepinephrine levels and increased dopamine levels, thereby potentially improving cardiac function and mitigating the symptoms of heart failure.
Used in Pharmaceutical Research:
In the context of pharmaceutical research, Nepicastat hydrochloride serves as a valuable tool for studying the roles of dopamine β-hydroxylase in various physiological and pathological processes. Its high selectivity for DBH makes it an ideal candidate for investigating enzyme inhibition and related pharmacological effects, which can contribute to the development of new treatments for cardiovascular and other diseases.
Used in Behavioral Neuroscience:
Nepicastat hydrochloride also finds application in behavioral neuroscience, particularly in research focused on the neurochemical basis of drug-seeking behavior and addiction. Its ability to modulate the progressive ratio response for cocaine and reduce reinstatement of cocaine-seeking behavior in animal models makes it a useful compound for exploring the underlying mechanisms of addiction and potential therapeutic interventions.
references
[1]. stanley wc, li b, bonhaus dw, et al. catecholamine modulatory effects of nepicastat (rs-25560-197), a novel, potent and selective inhibitor of dopamine-beta-hydroxylase. br j pharmacol, 1997, 121(8): 1803-1809.[2]. stanley wc, lee k, johnson lg, et al. cardiovascular effects of nepicastat (rs-25560-197), a novel dopamine beta-hydroxylase inhibitor. j cardiovasc pharmacol, 1998, 31(6): 963-970.[3]. devoto p, flore g, saba p, et al. the dopamine beta-hydroxylase inhibitor nepicastat increases dopamine release and potentiates psychostimulant-induced dopamine release in the prefrontal cortex. addict biol, 2014, 19(4): 612-622.
Check Digit Verification of cas no
The CAS Registry Mumber 170151-24-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,0,1,5 and 1 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 170151-24:
(8*1)+(7*7)+(6*0)+(5*1)+(4*5)+(3*1)+(2*2)+(1*4)=93
93 % 10 = 3
So 170151-24-3 is a valid CAS Registry Number.
