1703-43-1

Basic information

• Product Name: [3-(dimethylamino)phenyl](pyrrolidin-1-yl)methanone
• Synonyms: Methanone, [3-(dimethylamino)phenyl]-1-pyrrolidinyl-
• CAS NO: 1703-43-1
• Molecular Formula: C₁₃H₁₈N₂O
• Molecular Weight: 218.2948
• Mol File: 1703-43-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 384°C at 760 mmHg
• Flash Point: 172°C
• Density: 1.12g/cm³
• Vapor Pressure: 4.21E-06mmHg at 25°C
• Refractive Index: 1.592
• PKA: 4.09±0.10(Predicted)
• CAS DataBase Reference: [3-(dimethylamino)phenyl](pyrrolidin-1-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: [3-(dimethylamino)phenyl](pyrrolidin-1-yl)methanone(1703-43-1)
• EPA Substance Registry System: [3-(dimethylamino)phenyl](pyrrolidin-1-yl)methanone(1703-43-1)

Safety Data

• Hazardous Substances Data: 1703-43-1(Hazardous Substances Data)

Upstream product

• 123-75-1 pyrrolidine 
• 178752-79-9 3-(N,N-dimethylamino)phenylboronic acid 
• 1622923-36-7 (ethylthiotrifluoroborate)methane dimethyliminium zwitterion 

Relevant articles and documents

Catalytic Synthesis of Potassium Acyltrifluoroborates (KATs) from Boronic Acids and the Thioimidate KAT Transfer Reagent

We report the synthesis of potassium acyltrifluoroborates (KATs) by a palladium-catalyzed cross-coupling of boronic acids and the thioimidate KAT transfer reagent. The combination of widely available aryl- and vinylboronic acids with commercially available thioimidate 1 using catalytic PdII and a CuII additive enables the preparation of KATs in high yields and with good functional group tolerance. This formal insertion of CO into organoboronic acids can also be applied to boronic acid pinacol esters and potassium organotrifluoroborates using a slightly modified procedure. The cross-coupling can be telescoped into the one-pot synthesis of amides and α-aminotrifluoroborates by exploiting the unique chemistry of KATs and their trifluoroborate iminium (TIM) derivatives.